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Cancers
Special Issues
Tumor-Initiating Cells in Breast Cancer: From Bench to Bedside
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Tumor-Initiating Cells in Breast Cancer: From Bench to Bedside

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 1421

Special Issue Editor

Dr. Spiros Vlahopoulos

E-Mail Website
Guest Editor
First Department of Pediatrics, National and Kapodistrian University of Athens, 11527 Goudi-Athens, Greece
Interests: cancer biology; leukemia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The recent years have witnessed substantial progress in research on breast cancer stem cell properties. However, the most important challenge that remains to be addressed is the applicationof research findings for the benefit of patients.

Research on the influence of the microenvironment continues to make critical contributions to progress in the field. In this vein, studies of cellular transitions and interactions that affect immunity, inflammation and homeostasis, can lead to the development of methods that employ host factors to control the disease.

We invite manuscripts that add the dimension of translational research: at least in the discussion, a critical analysis of the significance of research findings for patient care. Research methodically examining the translational and prognostic value of cellular and molecular factors is also welcome.

Dr. Spiros Vlahopoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • cancer stem cell
  • tissue microenvironment
  • epithelial–mesenchymal transition
  • mesenchymal–epithelial transition

Published Papers (1 paper)

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Review

30 pages, 2244 KiB  
Review
Critical Roles of SRC-3 in the Development and Progression of Breast Cancer, Rendering It a Prospective Clinical Target
by Lokman Varisli, Garrett M. Dancik, Veysel Tolan and Spiros Vlahopoulos
Cancers 2023, 15(21), 5242; https://doi.org/10.3390/cancers15215242 - 31 Oct 2023
Cited by 1 | Viewed by 1157
Abstract
Breast cancer (BCa) is the most frequently diagnosed malignant tumor in women and is also one of the leading causes of cancer-related death. Most breast tumors are hormone-dependent and estrogen signaling plays a critical role in promoting the survival and malignant behaviors of [...] Read more.
Breast cancer (BCa) is the most frequently diagnosed malignant tumor in women and is also one of the leading causes of cancer-related death. Most breast tumors are hormone-dependent and estrogen signaling plays a critical role in promoting the survival and malignant behaviors of these cells. Estrogen signaling involves ligand-activated cytoplasmic estrogen receptors that translocate to the nucleus with various co-regulators, such as steroid receptor co-activator (SRC) family members, and bind to the promoters of target genes and regulate their expression. SRC-3 is a member of this family that interacts with, and enhances, the transcriptional activity of the ligand activated estrogen receptor. Although SRC-3 has important roles in normal homeostasis and developmental processes, it has been shown to be amplified and overexpressed in breast cancer and to promote malignancy. The malignancy-promoting potential of SRC-3 is diverse and involves both promoting malignant behavior of tumor cells and creating a tumor microenvironment that has an immunosuppressive phenotype. SRC-3 also inhibits the recruitment of tumor-infiltrating lymphocytes with effector function and promotes stemness. Furthermore, SRC-3 is also involved in the development of resistance to hormone therapy and immunotherapy during breast cancer treatment. The versatility of SRC-3 in promoting breast cancer malignancy in this way makes it a good target, and methodical targeting of SRC-3 probably will be important for the success of breast cancer treatment. Full article
(This article belongs to the Special Issue Tumor-Initiating Cells in Breast Cancer: From Bench to Bedside)
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