Special Issue "Genetics of Ovarian Cancer"
Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 646
2. Medway NHS Foundation Trust, Windmill Road, Gillingham ME7 5NY, Kent, UK
3. Kent Medway Medical School, University of Kent, Canterbury CT2 7LX, Kent, UK
4. AELIA Organization, 9(th)Km Thessaloniki-Thermi, 57001 Thessaloniki, Greece
Interests: prostate cancer; renal cancer; ovarian cancer; homologous recombination of DNA; PARP inhibitors; cervical cancer; carcinoma of unknown primary; colorectal cancer; cancer and autoimmune diseases; biomarkers
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2. 10Department of Oncology, Guy's and St Thomas' Hospital, London SE1 9RT, UK
3. School of Cancer & Pharmaceutical Sciences, King's College London, Strand, London WC2R 2LS, UK
Interests: novel MRI techniques; ovarian cancer;prostate cancer
Epithelial ovarian cancers (EOC), characterised by recurrent, persistent disease and the rapid acquisition of chemotherapy resistance, remain one of the most lethal gynaecological malignancies. DNA damage is one of the hallmarks of cancer. Among EOC, the high-grade serous subtype harbours a defect in at least one DNA damage response (DDR) pathway. Defective DDR results from a variety of lesions affecting homologous recombination (HR) and nonhomologous end joining (NHEJ) for double strand breaks, base excision repair (BER), and nucleotide excision repair (NER) for single strand breaks and mismatch repair (MMR).
We are pleased to invite you to submit your manuscripts and help the community to understand that DDR pathways are essential in order to optimize the therapeutic choices, as well as highlight the importance of designing biomarker-driven clinical trials. Poly(ADP-ribose) polymerase (PARP) inhibitors are a well-established treatment of EOC. Moreover, combinations of PARP inhibitors with drugs that inhibit HR may sensitise EOC with a primary or secondary HR proficiency to PARP inhibitors and potentially expand their use beyond HR-deficient ovarian cancers. Regarding this, PARP inhibitors may be combined separately with anti-angiogenics and immune checkpoint inhibitors as well as with phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), mammalian target of rapamycin (mTOR), WEE1, mitogen-activated protein kinase (MEK), and cyclin-dependent kinase (CDK) 4/6 inhibitors, or even with standard chemotherapy.
Through this Special Issue, we aim to shed light on the mechanisms of DDR, the potential for genomic analysis of ovarian cancer, and therapeutics of PARP inhibitors, along with predictive biomarkers.
This Special Issue welcomes manuscripts that include, though it is not limited to, the following topics:
- EOC risk assessment in the era of next-generation sequencing;
- Predictive and prognostic biomarkers in EOC;
- DNA damage response;
- PARP inhibitors in EOC;
- PARP inhibitors in combination with other therapies;
- Immunotherapy in EOC;
We look forward to receiving your contributions.
Dr. Stergios Boussios
Dr. Sola Adeleke
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- epithelial ovarian cancer
- translational research
- DNA damage response
- PARP inhibitors