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Cancers
Special Issues
Aging and Cancers
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Aging and Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 15 November 2024 | Viewed by 4743

Special Issue Editor

Dr. Fabio Marongiu

E-Mail Website
Guest Editor
Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy
Interests: the role of tissue microenvironment in the development and progression of cancer; importance aging; tissue pattern formation; cell competition; cell senescence

Special Issue Information

Dear Colleagues,

Aging and cancer both result from complex biological processes whose intricacies continue to challenge and stimulate generations of researchers in their respective fields. From this perspective, one would deem any attempt to combine the two topics as inappropriate and counterproductive in improving our unravelling capacity. Yet, studies over the past several decades have repeatedly suggested that aging and cancer are mechanistically related, other than being temporally associated. This line of thinking is gaining more and more momentum based on recent findings documenting the widespread changes occurring in the aged tissue landscapes, some of which bear direct relevance to the emergence of neoplastic diseases. In fact, the age-associated alterations in tissue/organismal context stand as a major factor fueling cancer development in the elderly population.

Within this framework, this Special Issue will highlight both biological and molecular pathways (including genetic and epigenetic) that can help explain the link between aging and cancer.

Dr. Fabio Marongiu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • cancer development
  • cell competition
  • tissue maintenance and decline
  • cell senescence
  • immune surveillance
  • clonal evolution
  • tissue pattern

Published Papers (2 papers)

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9 pages, 570 KiB  
Perspective
A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression
by Qiuyang Zhang and S. Michal Jazwinski
Cancers 2022, 14(21), 5185; https://doi.org/10.3390/cancers14215185 - 22 Oct 2022
Cited by 1 | Viewed by 1346
Abstract
Cancer is a disease of aging, but most studies on cancer are in young but not aged animal models, and cancer clinical trials are rarely performed in older adults. Recognition of the connections between aging and cancer and improvement of treatment for elderly [...] Read more.
Cancer is a disease of aging, but most studies on cancer are in young but not aged animal models, and cancer clinical trials are rarely performed in older adults. Recognition of the connections between aging and cancer and improvement of treatment for elderly cancer patients has become one of the most critical medical issues with the global increase in the elderly population. Mouse models are essential experimental tools for understanding the molecular mechanisms of complex processes and related gene pathways of biological aging. However, few mouse models can be used to understand the role of aging in cancer development and the underlying mechanisms. One of the hallmarks of aging is chronic inflammation, often called inflammaging. This is our rationale for examining the role of aging-related inflammation in prostate cancer, a major aging malignancy. We have now developed a novel method to generate age-related cancer models in mice to better understand how age impacts cancer initiation and progression in the natural aging process. We discuss its application to elucidate some of the contributing mechanisms. Full article
(This article belongs to the Special Issue Aging and Cancers)
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12 pages, 671 KiB  
Perspective
Stem-Cell Theory of Cancer: Implications for Antiaging and Anticancer Strategies
by Shi-Ming Tu and Louis L. Pisters
Cancers 2022, 14(5), 1338; https://doi.org/10.3390/cancers14051338 - 04 Mar 2022
Cited by 3 | Viewed by 2794
Abstract
A stem-cell theory of cancer predicates that not only does the cell affect the niche, the niche also affects the cell. It implicates that even though genetic makeup may be supreme, cellular context is key. When we attempt to solve the mystery of [...] Read more.
A stem-cell theory of cancer predicates that not only does the cell affect the niche, the niche also affects the cell. It implicates that even though genetic makeup may be supreme, cellular context is key. When we attempt to solve the mystery of a long cancer-free life, perhaps we need to search no further than the genetics and epigenetics of the naked mole-rat. When we try to unlock the secrets in the longevity and quality of life, perhaps we need to look no further than the lifestyle and habits of the super centenarians. We speculate that people with Down’s syndrome and progeria age faster but have fewer cancers, because they are depleted of stem cells, and, as a consequence, have fewer opportunities for stem cell defects that could predispose them to the development of cancer. We contemplate whether these incredible experiments of nature may provide irrefutable evidence that cancer is a stem-cell disease—fewer aberrant stem cells, fewer cancers; no defective stem cells, no cancer. In this perspective, we investigate a stem-cell origin of aging and cancer. We elaborate an intriguing inverse relationship between longevity and malignancy in the naked mole-rat, in Down’s syndrome, and in progeria. We postulate that stem-cell pools and stemness factors may affect aging and dictate cancer. We propose that a healthy microbiome may protect and preserve stem cell reserves and provide meaningful antiaging effects and anticancer benefits. Full article
(This article belongs to the Special Issue Aging and Cancers)
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