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Cancers
Special Issues
Chemotherapy and Treatment: Metastasis of Colorectal Cancer
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Chemotherapy and Treatment: Metastasis of Colorectal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 861

Special Issue Editor

Dr. Michela Roberto

E-Mail Website
Guest Editor
Policlinico Umberto I University Hospital, Viale del Policlinico, 155, 00161 Roma RM, Italy
Interests: genitourinary cancer; skin cancer; chemotherapy; target therapy; biomarkers

Special Issue Information

Dear Colleagues,

Colorectal tumorigenesis is a multistep process that involves an accumulation of multiple successive genetic alterations, such as chromosomal abnormalities, gene mutations and epigenetic changes, that induce a neoplastic transformation of the colic epithelium. Some of these alterations, with a well-established prognostic and predictive role, guide the therapeutic algorithm of metastatic CRC and are used to make personalized treatment decisions in CRC (KRAS, NRAS and BRAF), while the role of several other genetic mutations is still debated and not well established in clinical practice.

This Special Issue prompts researchers to obtain preclinical insights in CRC through studies. In addition to general clinical practice articles on metastatic CRC, reviews on innovative molecular mechanisms or gene alterations involved in CRC genesis, prognosis and response to chemotherapy are welcomed.

Dr. Michela Roberto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metastatic colorectal cancer (mCRC)
  • next-generation sequence (NGS)
  • biomarker
  • prognosis
  • molecular mechanisms

Published Papers (1 paper)

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Research

12 pages, 2920 KiB  
Article
Detection and Real-Time Surgical Assessment of Colorectal Liver Metastases Using Near-Infrared Fluorescence Imaging during Laparoscopic and Robotic-Assisted Resections
by Gaetano Piccolo, Matteo Barabino, Giorgio Ghilardi, Riccardo Masserano, Francesca Lecchi, Guglielmo Niccolò Piozzi and Paolo Pietro Bianchi
Cancers 2024, 16(9), 1641; https://doi.org/10.3390/cancers16091641 - 24 Apr 2024
Viewed by 235
Abstract
Background: The European Association of Endoscopic Surgery (EAES) recommends, with strong evidence, the use of indocyanine green (ICG) fluorescence imaging combined with intraoperative ultrasound (IOUS) to improve identification of superficial liver tumors. This study reports the use of ICG for the detection of [...] Read more.
Background: The European Association of Endoscopic Surgery (EAES) recommends, with strong evidence, the use of indocyanine green (ICG) fluorescence imaging combined with intraoperative ultrasound (IOUS) to improve identification of superficial liver tumors. This study reports the use of ICG for the detection of colorectal liver metastases (CRLMs) during minimally invasive liver resection. Methods: A single-center consecutive series of minimally invasive (laparoscopic and robotic) hepatic resections for CRLMs was prospectively evaluated (April 2019 and October 2023). Results: A total of 25 patients were enrolled—11 undergoing laparoscopic and 14 undergoing robotic procedures. The median age was 65 (range 50–85) years. Fifty CRLMs were detected: twenty superficial, eight exophytic, seven shallow (<8 mm from the hepatic surface), and fifteen deep (>10 mm from the hepatic surface) lesions. The detection rates of CRLMs through preoperative imaging, laparoscopic ultrasound (LUS), ICG fluorescence, and combined modalities (ICG and LUS) were 88%, 90%, 68%, and 100%, respectively. ICG fluorescence staining allowed us to detect five small additional superficial lesions (not identified with other preoperative/intraoperative techniques). However, two lesions were false positive fluorescence accumulations. All rim fluorescence pattern lesions were CRLMs. ICG fluorescence was used as a real-time guide to assess surgical margins during parenchymal-sparing liver resections. All patients with integrity of the fluorescent rim around the CRLM displayed a radical resection during histopathological analysis. Four patients (8%) with a protruding rim or residual rim patterns had positive resection margins. Conclusions: ICG fluorescence imaging can be integrated with other conventional intraoperative imaging techniques to optimize intraoperative staging. Rim fluorescence proved to be a valid indicator of the resection margins: by removing the entire fluorescent area, a tumor-negative resection (R0) is achieved. Full article
(This article belongs to the Special Issue Chemotherapy and Treatment: Metastasis of Colorectal Cancer)
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