Prostate Cancer: Molecular Imaging and Magnetic Resonance Imaging (MRI)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1480

Special Issue Editor


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Guest Editor
1. Department of Urology, Humanitas Research Hospital, IRCCS, Rozzano, Milan, Italy
2. Onze Lieve Vrouw Hospital, Aalst, Belgium
Interests: urologic oncology; diagnosis; treatment; surgical training; robotic surgery
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Special Issue Information

Dear Colleagues,

Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Accurate diagnosis and staging are crucial for determining the appropriate treatment approach and predicting patient outcomes. Over the past few years, magnetic resonance imaging (MRI) and molecular imaging have revolutionized the diagnostic‒therapeutic pathway of prostate cancer. MRI has transformed prostate gland imaging, offering high-resolution anatomical details and functional information. Multiparametric MRI, combining T2-weighted imaging, diffusion-weighted imaging, and dynamic contrast-enhanced imaging, enhances the detection, localization, and characterization of prostate tumors. Molecular imaging techniques, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), enable the visualization and characterization of specific molecular targets and metabolic processes associated with prostate cancer. These cutting-edge techniques offer invaluable insights into tumor aggressiveness, lymph node involvement, and distant metastases. Additionally, emerging techniques such as magnetic resonance spectroscopy and radiomics analysis offer further understanding of tumor biology and behavior. The integration of molecular imaging and MRI holds great potential in improving the accuracy of prostate cancer diagnosis, risk stratification, and treatment planning, ultimately leading to more personalized approaches and improved patient outcomes.

Nevertheless, there are several open issues that researchers and clinicians must address. Standardized protocols and criteria are needed to ensure consistent and reliable results across different centers and studies. Cost-effectiveness and accessibility concerns need to be addressed to make these advanced imaging modalities widely available. Integration with other diagnostic modalities, such as prostate biopsy or biomarkers, is of utmost importance to enhance overall diagnostic accuracy. Furthermore, long-term outcome studies are crucial to evaluate the prognostic value of molecular imaging and MRI in prostate cancer. Understanding the correlation between these imaging modalities, treatment response, disease progression, and overall survival is pivotal in establishing their role in clinical practice.

This Special Issue aims to shed light on the current state of molecular imaging and MRI for prostate cancer, with a particular focus on addressing the aforementioned challenges. By showcasing the latest research and advancements in this field, we strive to advance the field of molecular imaging and MRI for prostate cancer and pave the way for more precise and personalized approaches in its management.

Dr. Marco Paciotti
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • prostate cancer
  • prostate imaging
  • diagnosis
  • clinical staging
  • magnetic resonance imaging (MRI)
  • fusion biopsy
  • molecular imaging
  • positron emission tomography (PET)
  • PSMA PET/CT
  • PSMA-based therapy

Published Papers (1 paper)

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Research

14 pages, 1209 KiB  
Article
Application of 18F-PSMA-1007 PET/MR Imaging in Early Biochemical Recurrence of Prostate Cancer: Results of a Prospective Study of 60 Patients with Very Low PSA Levels ≤ 0.5 ng/mL
by Małgorzata Mojsak, Piotr Szumowski, Anna Amelian, Marcin Hladunski, Bożena Kubas, Janusz Myśliwiec, Jan Kochanowicz and Marcin Moniuszko
Cancers 2023, 15(16), 4185; https://doi.org/10.3390/cancers15164185 - 20 Aug 2023
Cited by 1 | Viewed by 1123
Abstract
The use of 18F-PSMA-1007 and the role of PET/MR in the diagnosis of prostate cancer are not conclusively confirmed. There are reports indicating the potential pros and cons of using 18F-PSMA-1007 as well as the PET/MR technique in prostate cancer recurrence, but they [...] Read more.
The use of 18F-PSMA-1007 and the role of PET/MR in the diagnosis of prostate cancer are not conclusively confirmed. There are reports indicating the potential pros and cons of using 18F-PSMA-1007 as well as the PET/MR technique in prostate cancer recurrence, but they are not yet included in the EAU guidelines. The aim of the study was to assess the effectiveness of 18F-PSMA-1007 PET/MR in detecting BCR lesions at very low PSA levels <0.5 ng/mL. Methods: Sixty patients with BCR after radical prostatectomy (RP) with PSA ranged 0.1–0.5 ng/mL were enrolled in a prospective study. All patients underwent simultaneous whole-body and pelvic 18F-PSMA-1007 PET/MR. The obtained results were verified by 12-month follow-up. Results: Fifty-three lesions were detected in 45 patients with 75% detection rate. The mean PSA value was 0.31 ng/mL. Of all PSMA-positive foci, 91% were localized in the pelvis, and only 9% of lesions were located in the extrapelvic region. Local recurrences were detected in 29%, PSMA-positive lymph nodes were detected in 64% of patients and bone metastases lesions were detected in 7% of patients. Conclusions: 18F-PSMA-1007 PET/MR seems to be an excellent diagnostic tool in patients with early BCR with very low PSA levels, especially with dt PSA < 6 months. The synergistic effect of combining 18F-PSMA-1007 and whole-body PET/MR with precise multiparametric assessment of pelvic lesions is of particular benefit in early BCR. Full article
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