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Cancers
Special Issues
Setting the Standards for Malignancies of the Nose Vestibule
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Setting the Standards for Malignancies of the Nose Vestibule

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2559

Special Issue Editors

Prof. Dr. Francesco Bussu

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Guest Editor
Department of Medical, Surgical and Experimental Science, University of Sassari, 07100 Sassari, Italy
Interests: head and neck surgery and oncology; facial reanimation; nose vestibule; molecular characterization; laryngeal surgery; HPV-driven carcinogenesis; TNM staging
Dr. Luca Tagliaferri

E-Mail Website
Guest Editor
Gemelli ART (Advanced Radiation Therapy), Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
Interests: interventional radiotherapy (brachytherapy); metabolic radiotherapy; medical software development; eye cancer; vulvar cancer; skin cancer; head and neck cancer; prostate cancer
Prof. Dr. Piero Nicolai

E-Mail Website
Guest Editor
Section of Otolaryngology—Head and Neck Surgery, Department of Neurosciences, University of Padova, Padova, Italy
Interests: head and neck surgery and oncology; endoscopic sinus surgery for benign and malignant diseases; sinonasal pathology; integrated treatments; anterior skull base surgery and oncology

Special Issue Information

Dear Colleagues,

The Special Issue will include papers dealing with all the steps of management (from diagnosis to treatment and follow-up) and all the specific aspects (histology, clinical features, prognosis, biology) of malignancies arising in the nose vestibule (NV) as well as adjacent mucosal and cutaneous regions.

Particular attention will be provided to the peculiar aspects of NV malignancies and the common mistakes in their management, including the differences with malignancies arising in adjacent mucosal and cutaneous regions, as well as the misdiagnosis with primary skin malignancies, the flaws of current staging systems, the peculiar surgical reconstructive issues, the results of prosthetic rehabilitation, and the difficult definition of the real prevalence of such malignancies.

In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Prof. Dr. Francesco Bussu
Dr. Luca Tagliaferri
Prof. Dr. Piero Nicolai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nose malignancies
  • TNM staging of the nose and paranasal sinuses
  • interventional radiotherapy
  • brachytherapy
  • external beam radiotherapy
  • skin malignancies
  • nose reconstruction
  • nose function
  • nose prosthesis
  • epithesis

Published Papers (2 papers)

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Research

10 pages, 768 KiB  
Article
Validation of the “Rome” Classification for Squamous Cell Carcinoma of the Nasal Vestibule
by Willem Frederik Julius Scheurleer, Mischa de Ridder, Luca Tagliaferri, Claudia Crescio, Claudio Parrilla, Gian Carlo Mattiucci, Bruno Fionda, Alberto Deganello, Jacopo Galli, Remco de Bree, Johannes A. Rijken and Francesco Bussu
Cancers 2024, 16(1), 37; https://doi.org/10.3390/cancers16010037 - 20 Dec 2023
Viewed by 771
Abstract
Squamous cell carcinoma of the nasal vestibule is considered a rare malignancy that differs from other sinonasal malignancies in many respects. Four staging systems currently exist for this disease, the most recent addition being the “Rome” classification. This study assesses the use of [...] Read more.
Squamous cell carcinoma of the nasal vestibule is considered a rare malignancy that differs from other sinonasal malignancies in many respects. Four staging systems currently exist for this disease, the most recent addition being the “Rome” classification. This study assesses the use of this new classification and its prognostic value regarding various outcome measures. A retrospective multicenter cohort study of patients with a primary squamous cell carcinoma of the nasal vestibule who were treated in three tertiary head and neck oncology referral centers was conducted. A total of 149 patients were included. The median follow-up duration was 27 months. Five-year locoregional control (LRC), disease-specific survival (DSS), and overall survival (OS) were 81.6%, 90.1, and 62.5% respectively. A statistically significant association was observed between the Rome classification and all survival outcomes in both univariable and multivariable analyses. Moreover, it appeared to perform better than the Union for International Cancer Control TNM classification for tumors of the nasal cavity and paranasal sinuses. The new Rome classification can be used effectively and is associated with LRC, DSS, and OS. However, it requires further validation in a larger (prospective) study population. Full article
(This article belongs to the Special Issue Setting the Standards for Malignancies of the Nose Vestibule)
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10 pages, 1400 KiB  
Article
Evaluation of Staging Systems for Cancer of the Nasal Vestibule
by Willem Frederik Julius Scheurleer, Luca Tagliaferri, Johannes A. Rijken, Claudia Crescio, Davide Rizzo, Gian Carlo Mattiucci, Frank A. Pameijer, Remco de Bree, Bruno Fionda, Mischa de Ridder and Francesco Bussu
Cancers 2023, 15(11), 3028; https://doi.org/10.3390/cancers15113028 - 01 Jun 2023
Cited by 3 | Viewed by 1420
Abstract
Squamous cell carcinoma of the nasal vestibule is reported to account for less than one percent of all head and neck malignancies. It lacks a designated WHO ICD-O topography code, and multiple systems are available for the staging of this disease, which results [...] Read more.
Squamous cell carcinoma of the nasal vestibule is reported to account for less than one percent of all head and neck malignancies. It lacks a designated WHO ICD-O topography code, and multiple systems are available for the staging of this disease, which results in unwanted variability and the subsequent poor reliability of data. The aim of this study was to evaluate the currently available staging systems for cancer of the nasal vestibule, including the recently introduced classification by Bussu et al., which built on Wang’s original concept but with clearer anatomical cutoffs. Different staging systems for cancer of the nasal vestibule (UICC nasal cavity, UICC skin cancer of the head and neck, Wang and Bussu et al.) were evaluated via a retrospective analysis of 148 patients. The staging system, per Bussu et al., had the most balanced allocation of patients among the stages. When using the Wang classification as a reference, stage migration occurred less frequently with the Bussu classification. The widespread adoption of a single staging system, as well as the introduction of a designated topography code for cancer of the nasal vestibule, could lead to more uniformity in data reporting and improve an understanding of the incidence and disease outcome. The newly proposed carcinoma of the nasal vestibule classification by Bussu et al. has the potential to improve the staging and allocation among stages. Further analysis of survival data is needed to assess which classification system is best suited for nasal vestibule carcinoma. Full article
(This article belongs to the Special Issue Setting the Standards for Malignancies of the Nose Vestibule)
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