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7.4
5.2
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Cancers
Special Issues
Post-transcriptional Regulation of Cancer-Related Processes
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Post-transcriptional Regulation of Cancer-Related Processes

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 1 December 2024 | Viewed by 1234

Special Issue Editor

Dr. Cyril Sobolewski

E-Mail Website
Guest Editor
U1286-INFINITE-Institute for Translational Research in Inflammation, CHU Lille, Inserm, University Lille, F-59000 Lille, France
Interests: cancer; microRNAs; chronic liver diseases; RNA-binding proteins

Special Issue Information

Dear Colleagues,

Non-coding RNAs, (e.g., microRNAs, long-non-coding RNAs) and RNA-Binding Proteins (RBPs) play a central role in the development of many cancers, as well as in chronic inflammatory/metabolic diseases fostering carcinogenesis. Deciphering the role of these post-transcriptional regulators of gene expression is therefore of major interest to characterize cancers and develop new and efficient therapeutic options. The aim of this Special Issue is to highlight the most recent advances regarding the post-transcriptional regulation of gene expression in cancer-related processes, with an emphasis for the following topics:

  1. MicroRNAs, circulating miRNAs, long-non-coding RNA: functions/regulation (e.g., editing).
  2. RNA-Binding Proteins’ functions in cancers.
  3. Novel therapeutic approaches to target non-coding RNA and RBPs.

Dr. Cyril Sobolewski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microRNAs
  • long-non-coding RNA
  • RNA-binding proteins
  • stress granules
  • P-bodies

Published Papers (1 paper)

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Review

42 pages, 9916 KiB  
Review
MiRNAs in Alcohol-Related Liver Diseases and Hepatocellular Carcinoma: A Step toward New Therapeutic Approaches?
by Mickaël Jouve, Rodolphe Carpentier, Sarra Kraiem, Noémie Legrand and Cyril Sobolewski
Cancers 2023, 15(23), 5557; https://doi.org/10.3390/cancers15235557 - 23 Nov 2023
Cited by 2 | Viewed by 1019
Abstract
Alcohol-related Liver Disease (ALD) is the primary cause of chronic liver disorders and hepatocellular carcinoma (HCC) development in developed countries and thus represents a major public health concern. Unfortunately, few therapeutic options are available for ALD and HCC, except liver transplantation or tumor [...] Read more.
Alcohol-related Liver Disease (ALD) is the primary cause of chronic liver disorders and hepatocellular carcinoma (HCC) development in developed countries and thus represents a major public health concern. Unfortunately, few therapeutic options are available for ALD and HCC, except liver transplantation or tumor resection for HCC. Deciphering the molecular mechanisms underlying the development of these diseases is therefore of major importance to identify early biomarkers and to design efficient therapeutic options. Increasing evidence indicate that epigenetic alterations play a central role in the development of ALD and HCC. Among them, microRNA importantly contribute to the development of this disease by controlling the expression of several genes involved in hepatic metabolism, inflammation, fibrosis, and carcinogenesis at the post-transcriptional level. In this review, we discuss the current knowledge about miRNAs’ functions in the different stages of ALD and their role in the progression toward carcinogenesis. We highlight that each stage of ALD is associated with deregulated miRNAs involved in hepatic carcinogenesis, and thus represent HCC-priming miRNAs. By using in silico approaches, we have uncovered new miRNAs potentially involved in HCC. Finally, we discuss the therapeutic potential of targeting miRNAs for the treatment of these diseases. Full article
(This article belongs to the Special Issue Post-transcriptional Regulation of Cancer-Related Processes)
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