Combination Therapy for Hepatocellular Carcinoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 707

Special Issue Editor


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Guest Editor
Department of Diagnostic and Interventional Radiology, Nara Medical University, Shijyocho 840, Kashihara City 634-8522, Japan
Interests: interventional radiology; interventional oncology; transcatheter therapy; liver cancer

Special Issue Information

Dear Colleagues,

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Despite advances in diagnosis and treatment, the prognosis for HCC patients remains unsatisfactory, with limited curative options available. Combination therapy, involving the use of multiple treatment modalities simultaneously or sequentially, has emerged as a promising strategy to improve patient outcomes. These may include surgical interventions, tumor ablation, transarterial chemoembolization (TACE), transarterial chemoinfusion (HAIC), radiation therapy, systemic therapies and others. In this Special Issue, we will address the challenges and future directions of combination therapy for HCC. These may encompass novel combination strategies and potential synergies, with emerging therapies such as molecular targeted agents and immune checkpoint inhibitors. The goal of this Special Issue is to gather a comprehensive collection of articles that explore the various aspects of combination therapy for HCC, by reviewing the latest research, clinical trials and expert opinions. Here, we aim to provide clinicians, researchers and allied professionals with valuable insights into the current landscape of combination therapy approaches, their efficacy and future directions. By examining the underlying rationale, exploring various treatment modalities and addressing future perspectives, this issue strives to contribute to the advancement of combination therapy strategies, ultimately improving outcomes for patients with HCC.

Dr. Toshihiro Tanaka
Guest Editor

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Keywords

  • hepatocellular carcinoma
  • combination therapy
  • multidisciplinary therapy
  • outcomes
  • prognosis

Published Papers (1 paper)

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Research

14 pages, 8437 KiB  
Article
Effects of Short-Term Lenvatinib Administration Prior to Transarterial Chemoembolization for Hepatocellular Carcinoma
by Tetsuya Tachiiri, Kiyoyuki Minamiguchi, Ryosuke Taiji, Takeshi Sato, Shohei Toyoda, Takeshi Matsumoto, Yuto Chanoki, Hideki Kunichika, Satoshi Yamauchi, Sho Shimizu, Hideyuki Nishiofuku, Nagaaki Marugami, Yuki Tsuji, Tadashi Namisaki, Hitoshi Yoshiji and Toshihiro Tanaka
Cancers 2024, 16(9), 1624; https://doi.org/10.3390/cancers16091624 - 23 Apr 2024
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Abstract
Aim: Transarterial chemoembolization (TACE) combined with lenvatinib, employing a 4-day lenvatinib administration followed by TACE without an interval (short-term LEN-TACE), was performed for hepatocellular carcinoma (HCC). The aim was to assess tumor hemodynamics following the 4-day lenvatinib and to evaluate the treatment outcomes [...] Read more.
Aim: Transarterial chemoembolization (TACE) combined with lenvatinib, employing a 4-day lenvatinib administration followed by TACE without an interval (short-term LEN-TACE), was performed for hepatocellular carcinoma (HCC). The aim was to assess tumor hemodynamics following the 4-day lenvatinib and to evaluate the treatment outcomes after the short-term LEN-TACE. Methods: 25 unresectable HCC patients received this combined therapy. Lenvatinib (4–12 mg) was administrated for 4 days prior to TACE. Perfusion CT scans were obtained before and after the lenvatinib administration. Either cTACE (76%) or DEB-TACE (24%) were performed. Results: intra-tumor blood flow significantly decreased after the 4-day lenvatinib (p < 0.05). The TACE procedure was successful with no severe adverse events in all patients. The overall complete response (CR) rate was 75% (cTACE 84%, DEB-TACE 40%). The lipiodol-washout ratio between 1 week and 4 months after cTACE correlated with the arterial flow reduction ratio by lenvatinib prior to TACE (r = −0.55). The 12-month progression-free survival (PFS) rate was 75.0%. Conclusions: The short-term LEN-TACE is feasible and safe, demonstrating promising outcomes with a high CR ratio, contributing to lipiodol retention in the tumor after cTACE, and extended PFS. To confirm the advantages of this treatment protocol, a prospective clinical trial is mandatory. Full article
(This article belongs to the Special Issue Combination Therapy for Hepatocellular Carcinoma)
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