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7.4
5.2
Journals
Cancers
Special Issues
Surgical Treatment of Spinal Tumors
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Surgical Treatment of Spinal Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 377

Special Issue Editors

Prof. Dr. Ziya Levent Gökaslan

E-Mail Website
Guest Editor
Department of Neurosurgery, The Warren Alpert Medical School, Providence, RI, USA
Interests: spine tumors
Dr. Patricia L Sullivan

E-Mail Website
Guest Editor
Department of Neurosurgery, The Warren Alpert Medical School, Providence, RI, USA
Interests: spine tumors

Special Issue Information

Dear Colleagues,

Surgical decompression and stabilization procedures for patients with metastatic spine tumors have been well supported since the publication of the Patchell study in 2005. A parallel body of literature has also grown to support en bloc resection for primary spinal tumors (such as chordoma). As surgeons incorporate these recommendations, it is critical to consider the recent advances in radiation and chemotherapy.

This Special Issue seeks to review medical, radiation, and surgical advances that impact the treatment of spine tumors. Original research articles and reviews are welcome. We look forward to receiving your contributions.

Prof. Dr. Ziya Levent Gökaslan
Dr. Patricia L Sullivan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metastasis
  • vertebral
  • primary tumor
  • sarcoma
  • chordoma
  • spine tumor
  • surgery
  • fusion

Published Papers (1 paper)

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Research

13 pages, 699 KiB  
Article
A Combined Cyto- and Histopathological Diagnostic Approach Reduces Time to Diagnosis and Time to Therapy in First Manifestation of Metastatic Spinal Disease: A Cohort Study
by Leon-Gordian Leonhardt, Annika Heuer, Martin Stangenberg, Malte Schroeder, Gabriel Schmidt, Lutz Welker, Gunhild von Amsberg, André Strahl, Lara Krüger, Marc Dreimann, Carsten Bokemeyer, Lennart Viezens and Anne Marie Asemissen
Cancers 2024, 16(9), 1659; https://doi.org/10.3390/cancers16091659 - 25 Apr 2024
Viewed by 132
Abstract
Malignant spinal lesions (MSLs) are frequently the first manifestation of malignant disease. Spinal care, diagnostic evaluation, and the initiation of systemic therapy are crucial for outcomes in patients (pts) with advanced cancer. However, histopathology (HP) may be time consuming. The additional evaluation of [...] Read more.
Malignant spinal lesions (MSLs) are frequently the first manifestation of malignant disease. Spinal care, diagnostic evaluation, and the initiation of systemic therapy are crucial for outcomes in patients (pts) with advanced cancer. However, histopathology (HP) may be time consuming. The additional evaluation of spinal lesions using cytopathology (CP) has the potential to reduce the time to diagnosis (TTD) and time to therapy (TTT). CP and HP specimens from spinal lesions were evaluated in parallel in 61 pts (CP/HP group). Furthermore, 139 pts in whom only HP was performed were analyzed (HP group). We analyzed the TTD of CP and HP within the CP/HP group. Furthermore, we compared the TTD and TTT between the groups. The mean TTD in CP was 1.7 ± 1.7 days (d) and 8.4 ± 3.6 d in HP (p < 0.001). In 13 pts in the CP/HP group (24.1%), specific therapy was initiated based on the CP findings in combination with imaging and biomarker results before completion of HP. The mean TTT in the CP/HP group was 21.0 ± 15.8 d and was significantly shorter compared to the HP group (28.6 ± 23.3 d) (p = 0.034). Concurrent CP for MSLs significantly reduces the TTD and TTT. As a result, incorporating concurrent CP for analyzing spinal lesions suspected of malignancy might have the potential to enhance pts’ quality of life and prognosis in advanced cancer. Therefore, we recommend implementing CP as a standard procedure for the evaluation of MSLs. Full article
(This article belongs to the Special Issue Surgical Treatment of Spinal Tumors)
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