Update on Pathogenesis and Treatment of Kaposi’s Sarcoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (5 April 2024) | Viewed by 1175

Special Issue Editor


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Guest Editor
1. Department of Physiopathology and Transplantation, University of Milan, Milan, Italy
2. Dermatology Unit – Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Pace, 9, Milan, Italy
Interests: Kaposi’s sarcoma; HHV8-associated malignancies; dermoscopy

Special Issue Information

Dear Colleagues,

Kaposi’s sarcoma is a rare, low-grade vascular neoplasm that is caused by Human Herpes Virus 8 (HHV-8) infection. In addition to HHV-8 infection, other factors are required in order to develop the disease, with the most important being impaired host immunity. Only a small number of infected subjects will develop Kaposi’s sarcoma, and patients with acquired immune deficiency syndrome or under immune suppressive treatments are more likely to develop this neoplasm.

Since the discovery of HHV-8 in 1994, much has been learned about its epidemiology; however, many aspects regarding pathophysiology and their application into clinical practice are not yet fully clarified. Indeed, in the era of immunotherapy and targeted therapies for different types of cancer, chemotherapy is still the most common modality of treatment for patients with Kaposi’s sarcoma.

This Special Issue will focus on the latest research results that contribute to the pathogenesis of Kaposi’s sarcoma and its management and outcomes. Original research or review articles are welcome.

Dr. Athanasia Tourlaki
Guest Editor

Manuscript Submission Information

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Keywords

  • Kaposi’s sarcoma
  • Human Herpes Virus 8 (HHV-8)
  • oncogenesis
  • chemotherapy
  • targeted therapy
  • immunotherapy

Published Papers (1 paper)

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Research

14 pages, 2111 KiB  
Article
Kaposi’s Sarcoma: Evaluation of Clinical Features, Treatment Outcomes, and Prognosis in a Single-Center Retrospective Case Series
by Irene Russo, Dario Marino, Claudia Cozzolino, Paolo Del Fiore, Fitnete Nerjaku, Silvia Finotto, Annamaria Cattelan, Maria Luisa Calabrò, Anna Belloni Fortina, Francesco Russano, Marcodomenico Mazza, Sara Galuppo, Elisabetta Bezzon, Marta Sbaraglia, Marco Krengli, Antonella Brunello, Simone Mocellin, Stefano Piaserico and Mauro Alaibac
Cancers 2024, 16(4), 691; https://doi.org/10.3390/cancers16040691 - 06 Feb 2024
Viewed by 903
Abstract
Kaposi’s sarcoma (KS) is a rare angioproliferative tumor classified in four different clinical–epidemiological forms. The diagnosis is based on histopathological and immunohistochemical analyses. The treatment is heterogeneous and includes several local and systemic therapeutic strategies. Methods: This is a retrospective cohort study including [...] Read more.
Kaposi’s sarcoma (KS) is a rare angioproliferative tumor classified in four different clinical–epidemiological forms. The diagnosis is based on histopathological and immunohistochemical analyses. The treatment is heterogeneous and includes several local and systemic therapeutic strategies. Methods: This is a retrospective cohort study including 86 KS patients treated between 1993 and 2022 at the University Hospital of Padua (AOPD) and at the Veneto Institute of Oncology (IOV). The data were extracted from an electronic database. Survival curves were generated using the Kaplan–Meier method, and Cox regression models were employed to explore associations with overall and disease-free survival. The male sex (89.53%), classical variant (43.02%), and cutaneous involvement (77.9%) were predominant. More than 61.6% of patients received a single treatment. Surgery, antiretroviral therapy, and chemotherapy were the mostly adopted approaches. A persistent response was observed in approximately 65% of patients, with a 22% relapse rate (at least 2 years). The overall survival ranges from 90 to 70% at 2 to 10 years after the diagnosis. Iatrogenic KS demonstrated a higher mortality (52.9%). This study reflects our experience in the management of KS. Comorbidities are very frequent, and treatments are heterogeneous. A multidisciplinary approach involving multiple referral specialists is essential for the appropriate management of this disease during diagnosis, treatment, and follow-up. Full article
(This article belongs to the Special Issue Update on Pathogenesis and Treatment of Kaposi’s Sarcoma)
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