New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1084

Special Issue Editors


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Guest Editor
Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu 879-5593, Japan
Interests: Helicobacter pylori; gastric cancer; cell cycle; immunohistochemistry; biliary duct cancer

E-Mail Website
Guest Editor
Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu 879-5593, Japan
Interests: Helicobacter pylori; gastric cancer; endoscopic procedure; capsule endoscopy; image enhancement endoscopy; gastroesophageal reflux disease; anisakidosis
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Special Issue Information

Dear Colleagues,

Although gastric cancer is declining due to the establishment of Helicobacter pylori (H. pylori) eradication therapy, there are still many gastric cancer deaths worldwide. New findings are still being found to overcome the disadvantages of gastric cancer in patients. Recently, it has been reported that H. pylori-infected patients and patients with intestinal metaplasia have a high diversity of intestinal microbiota, and there is an association with gastric cancer in the stomach microbiota. In addition, gastric cancer after H. pylori eradication has different characteristics from conventional H. pylori-associated gastric cancer, so we must continue to acquire new knowledge about this cancer type. In terms of treatment, minimally invasive therapy for early-stage gastric cancer has become widespread, and recently, chemotherapy, including immune checkpoint inhibitors, has been advancing at an rapid rate.

In this Special Issue, we will collect the latest findings in this new phase of gastric cancer.

Dr. Kazunari Murakami
Dr. Kazuhiro Mizukami
Guest Editors

Manuscript Submission Information

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Keywords

  • gastric cancer
  • microbiota
  • Helicobacter pylori
  • after Helicobacter pylori eradication therapy
  • chemotherapy
  • immune checkpoint inhibitor

Published Papers (1 paper)

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Research

15 pages, 2120 KiB  
Article
CA125 Kinetics as a Potential Biomarker for Peritoneal Metastasis Progression following Taxane-Plus-Ramucirumab Administration in Patients with Advanced Gastric Cancer
by Akira Ueda, Satoshi Yuki, Takayuki Ando, Ayumu Hosokawa, Naokatsu Nakada, Yosuke Kito, Iori Motoo, Ken Ito, Miho Sakumura, Yurika Nakayama, Yuko Ueda, Shinya Kajiura, Koji Nakashima, Kazuaki Harada, Yasuyuki Kawamoto, Yoshito Komatsu and Ichiro Yasuda
Cancers 2024, 16(5), 871; https://doi.org/10.3390/cancers16050871 - 22 Feb 2024
Viewed by 789
Abstract
Currently, no established marker exists for predicting peritoneal metastasis progression during chemotherapy, although they are major interruptive factors in sequential chemotherapy in patients with advanced gastric cancer (AGC). This multicenter retrospective study was conducted from June 2015 to July 2019, analyzing 73 patients [...] Read more.
Currently, no established marker exists for predicting peritoneal metastasis progression during chemotherapy, although they are major interruptive factors in sequential chemotherapy in patients with advanced gastric cancer (AGC). This multicenter retrospective study was conducted from June 2015 to July 2019, analyzing 73 patients with AGC who underwent taxane-plus-ramucirumab (TAX/RAM) therapy and had their serum carbohydrate antigen 125 (CA125) concentrations measured. Of 31 patients with elevated CA125 levels above a cutoff of 35 U/mL, 25 (80.6%) had peritoneal metastasis. The CA125 concentrations before TAX/RAM treatment were associated with ascites burden. The overall survival was significantly shorter in the CA125-elevated group. CA125 kinetics, measured at a median of 28 days after chemotherapy, were associated with the ascites response (complete or partial response: −1.86%/day; stable disease: 0.28%/day; progressive disease: 2.33%/day). Progression-free survival in the CA125-increased group, defined by an increase of 0.0067%/day using receiver operating characteristic curve analysis, was significantly poorer among patients with peritoneal metastases. In conclusion, this study highlights that CA125 kinetics can serve as an early predictor for the progression of peritoneal metastasis during TAX/RAM treatment. Full article
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