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A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 3892

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Special Issue Editor

Prof. Dr. Gyung-mo Son

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Guest Editor

Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea
Interests: colorectal cancer; surgical management; laparoscopic surgery

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the surgical management of colorectal cancer, highlighting critical aspects of surgical development. It aims to present the latest research on colorectal cancer surgery and its practical applications, offering insights that are able to enhance patient care pathways.

In recent years, there have been significant advancements in the field of surgical treatment for colorectal cancer. Minimally invasive approaches, such as laparoscopic, robotic, and single-port surgeries, have gained prominence. Moreover, the utilization of NIR cameras for image-guided surgery has been steadily increasing. The continuous development of surgical equipment and surgical techniques has contributed to the refinement of colorectal cancer surgery.

Of particular note is the potential capacity of these advancements in surgical and imaging technologies to bridge the gap in surgical outcomes attributed to differences in surgeons' experience. This progress has the capacity to empower less-experienced surgeons, enabling them to perform safer procedures and navigate their learning more effectively.

Furthermore, the recent expansion of real-time surgical information analysis through artificial intelligence is ushering in a new era, in which a wealth of information can be seamlessly provided to surgeons during procedures. These breakthroughs in surgical techniques exhibit potential regarding their ability to reduce complications in colorectal cancer surgeries, thus enhancing procedural safety and potentially improving long-term disease-free survival rates for cancer patients.

Prof. Dr. Gyung-mo Son
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

colorectal cancer
surgical management
minimally invasive surgery
laparoscopic surgery
robotic surgery
single port surgery
emergency surgery
image-guided surgery
enhanced recovery after surgery (ERAS)
systemic metastasis in colorectal cancer (involving the liver, lung, peritoneum, etc.)

Published Papers (4 papers)

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Research

17 pages, 2285 KiB

Open AccessArticle

Recurrence Patterns and Risk Factors after Curative Resection for Colorectal Cancer: Insights for Postoperative Surveillance Strategies

by Hyo Seon Ryu, Jin Kim, Ye Ryung Park, Eun Hae Cho, Jeong Min Choo, Ji-Seon Kim, Se-Jin Baek and Jung-Myun Kwak

Cancers 2023, 15(24), 5791; https://doi.org/10.3390/cancers15245791 - 10 Dec 2023

Viewed by 1250

Abstract

This study aimed to assess recurrence patterns and related risk factors following curative resection of colorectal cancer (CRC). This retrospective observational study was conducted at a tertiary care center, including 2622 patients with stage I–III CRC who underwent curative resection between 2008 and 2018. Hazard rates of recurrence were calculated using a hazard function. The primary outcome was the peak recurrence time after curative resection and secondary outcomes were prognostic factors associated with recurrence. Over a median follow-up period of 53 months, the overall, locoregional and systemic recurrence rates were 8.9%, 0.7%, and 8.5%, respectively. Recurrence rates were significantly higher for rectal cancer (14.9% overall, 4.4% locoregionally, and 12.3% systemically) than for colon cancer (all p < 0.001). The peak recurrence time was 11 months, with variations in hazard rates and curves depending on the tumor location, stage, and risk factors. Patients with AL or CRM involvement exhibited a distinct pattern, with a high hazard rate in the early postoperative period. Understanding these recurrence patterns and risk factors is crucial for establishing effective postoperative surveillance strategies. Our findings suggested that short-interval surveillance should be considered during the first 2 years post-surgery, particularly for high-risk patients who should receive early attention. Full article

(This article belongs to the Special Issue The Surgical Management of Colorectal Cancer)

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13 pages, 2225 KiB

Open AccessArticle

Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes

by Kenei Furukawa, Koichiro Haruki, Tomohiko Taniai, Mitsuru Yanagaki, Masashi Tsunematsu, Yoshiaki Tanji, Shunta Ishizaki, Yoshihiro Shirai, Shinji Onda and Toru Ikegami

Cancers 2023, 15(23), 5513; https://doi.org/10.3390/cancers15235513 - 22 Nov 2023

Viewed by 695

Abstract

Aim: The impact of occult vertebral fracture (OVF) on oncological outcomes after surgery has not been investigated, although its significance in orthopedics has been much debated recently. We evaluated the prognostic significance of OVF on the long-term outcomes of patients with colorectal liver metastases (CRLM) after hepatectomy. Methods: We included 140 patients with CRLM who underwent hepatectomy. OVF was identified using quantitative measurement and preoperative sagittal computed tomography image reconstruction from the 11th thoracic vertebra to the 5th lumber vertebra. Results: OVF was identified in 48 (34%) of the patients. In multivariate analysis, lymph node metastases (p < 0.01), multiple tumors (p = 0.02), extrahepatic lesions (p < 0.01), OVF (p < 0.01), intraoperative bleeding (p = 0.04), and curability 1 or 2 (p < 0.01) were independent and significant predictors of disease-free survival and extrahepatic lesions (p < 0.01), osteosarcopenia (p = 0.02), and OVF (p < 0.01) were independent and significant predictors of overall survival. A higher age, adjuvant chemotherapy for a primary lesion before metachronous liver metastases, osteopenia, and hypoalbuminemia were independent risk factors for OVF. Conclusions: The evaluation of preoperative OVF is a useful prognostic factor for risk stratification and clinical decision-making for patients with CRLM. Full article

(This article belongs to the Special Issue The Surgical Management of Colorectal Cancer)

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12 pages, 718 KiB

Open AccessArticle

Do Laparoscopic Approaches Ensure Oncological Safety and Prognosis for Serosa-Exposed Colon Cancer? A Comparative Study against the Open Approach

by Ji-Hyun Seo and In-Ja Park

Cancers 2023, 15(21), 5211; https://doi.org/10.3390/cancers15215211 - 30 Oct 2023

Viewed by 729

Abstract

The adoption of laparoscopic surgery in the management of serosa-exposed colorectal cancer has raised concerns. This study aimed to investigate whether laparoscopic surgery is associated with an increased risk of postoperative recurrence in patients undergoing resection for serosa-exposed colon cancer. A retrospective analysis was conducted on a cohort of 315 patients who underwent curative resection for pathologically confirmed T4a colon cancer without distant metastases at the Asan Medical Center between 2006 and 2015. Patients were categorized according to the surgical approach method: laparoscopic surgery (MIS group) versus open surgery (Open group). Multivariate analysis was employed to identify risk factors associated with overall survival (OS) and disease-free survival (DFS). The MIS group included 148 patients and the Open group had 167 patients. Of the total cohort, 106 patients (33.7%) experienced recurrence during the follow-up period. Rates, patterns, and time to recurrence were not different between groups. The MIS group (55.8%) showed more peritoneal metastasis compared to the Open group (44.4%) among recurrence sites, but it was not significant (p = 0.85). There was no significant difference in the five-year OS (73.5% vs. 78.4% p = 0.374) or DFS (62.0% vs. 64.6%; p = 0.61) between the Open and MIS groups. Age and the pathologic N stage were independently associated with OS, and the pathologic N stage was the only associated risk factor for DFS. The laparoscopic approach for serosa-exposed colon cancer did not compromise the DFS and OS. This study provides evidence that laparoscopic surgery does not compromise oncologic outcomes of patients with T4a colon cancer although peritoneal seeding is the most common type of disease failure of serosa-exposed colon cancer. Full article

(This article belongs to the Special Issue The Surgical Management of Colorectal Cancer)

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16 pages, 1195 KiB

Open AccessArticle

Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer

by Su Hyeong Park, Hye Seung Woo, In Kyung Hong and Eun Jung Park

Cancers 2023, 15(20), 5098; https://doi.org/10.3390/cancers15205098 - 22 Oct 2023

Viewed by 904

Abstract

Background: The Naples prognostic score (NPS) is a scoring system that reflects a patient’s systemic inflammatory and nutritional status. This study aimed to evaluate whether postoperative NPS is effective in assessing the prognosis of stage II–III colorectal cancer (CRC) patients compared with preoperative NPS. Methods: Between 2005 and 2012, a total of 164 patients diagnosed with stage II–III CRC, who underwent curative resection followed by adjuvant chemotherapy, were divided into two groups: Group 0–1 (NPS = 0–2) and Group 2 (NPS = 3 or 4). Preoperative NPS was calculated based on the results before surgeries, and postoperative NPS was assessed using the results obtained before adjuvant chemotherapy. Results: The overall survival of Group 0–1 was higher than that of Group 2 in both pre- and postoperative NPS assessments. According to the ROC curve analysis, the Area Under the Curve (AUC) ratio for postoperative NPS was 0.64, compared with 0.57 for preoperative NPS, 0.52 for the preoperative neutrophil–lymphocyte ratio (p = 0.032), and 0.51 for the preoperative platelet–lymphocyte ratio (p = 0.027). Conclusions: Postoperative NPS is effective in predicting the prognosis of stage II–III CRC patients who underwent curative resection followed by adjuvant chemotherapy. The use of NPS could be beneficial in evaluating the prognosis of CRC patients after surgeries. Full article

(This article belongs to the Special Issue The Surgical Management of Colorectal Cancer)

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