Palliative Radiotherapy in Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: closed (10 March 2024) | Viewed by 1159

Special Issue Editors


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Guest Editor
Palliative Care Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, FC, Italy
Interests: early palliative care; prognosis; palliative sedation
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Guest Editor
Radiation Oncology, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum—Bologna University, Bologna, Italy
Interests: palliative radiotherapy; radiotherapy of prostate cancer; radiotherapy of pancreatic cancer; radiotherapy of rectal cancer; radiotherapy of biliary cancer

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Guest Editor
IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, 47014 Meldola, Italy
Interests: the integration of radiotherapy and palliative care; early palliative care

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Guest Editor Assistant
Department of Experimental, Diagnostic and Specialty Medicine – DIMES, Alma Mater Studiorum University of Bologna, Via Albertoni 15, 40138 Bologna, Italy
Interests: cancer radiation

Special Issue Information

Dear Colleagues,

Palliative radiotherapy is well known for being an essential tool for symptom relief in patients with advanced cancer. However, little space is usually given to this resource in conference events and more generally in the education and permanent training of doctors and specialists working in oncology.

Furthermore, clinical research has only marginally addressed this issue, leaving large spaces without clear scientific evidence in a scenario in which the introduction of the concept of oligometastatic disease has produced gray areas without clear guidelines. Finally, the diffusion of palliative therapies makes it urgent to define paths of integration between pharmacological-supportive treatments and radiotherapy.

We hope that this Special Issue will gather and highlight the evidence needed to help optimize clinical practice in palliative radiotherapy and in particular to improve the integration of radiotherapy with other resources available today in the field of palliative therapies. We look forward to your contributions.

Prof. Dr. Marco Cesare Maltoni
Prof. Dr. Alessio Giuseppe Morganti
Dr. Romina Rossi
Guest Editors

Costanza Maria Donati
Guest Editor Assitant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

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Article
Adequacy of Pain Management in Patients Referred for Radiation Therapy: A Subanalysis of the Multicenter ARISE-1 Study
by Costanza M. Donati, Chiara Maria Maggiore, Marco Maltoni, Romina Rossi, Elena Nardi, Alice Zamagni, Giambattista Siepe, Filippo Mammini, Francesco Cellini, Alessia Di Rito, Maurizio Portaluri, Cristina De Tommaso, Anna Santacaterina, Consuelo Tamburella, Rossella Di Franco, Salvatore Parisi, Sabrina Cossa, Vincenzo Fusco, Antonella Bianculli, Pierpaolo Ziccarelli, Luigi Ziccarelli, Domenico Genovesi, Luciana Caravatta, Francesco Deodato, Gabriella Macchia, Francesco Fiorica, Giuseppe Napoli, Milly Buwenge and Alessio G. Morgantiadd Show full author list remove Hide full author list
Cancers 2024, 16(1), 109; https://doi.org/10.3390/cancers16010109 - 25 Dec 2023
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Abstract
Background: Pain is a prevalent symptom among cancer patients, and its management is crucial for improving their quality of life. However, pain management in cancer patients referred to radiotherapy (RT) departments is often inadequate, and limited research has been conducted on this specific [...] Read more.
Background: Pain is a prevalent symptom among cancer patients, and its management is crucial for improving their quality of life. However, pain management in cancer patients referred to radiotherapy (RT) departments is often inadequate, and limited research has been conducted on this specific population. This study aimed to assess the adequacy and effectiveness of pain management when patients are referred for RT. Moreover, we explored potential predictors of adequate pain management. Methods: This observational, prospective, multicenter cohort study included cancer patients aged 18 years or older who were referred to RT departments. A pain management assessment was conducted using the Pain Management Index (PMI), calculated by subtracting the pain score from the analgesic score (PMI < 0 indicated inadequate pain management). Univariate and multivariate analyses were performed to identify predictors of adequate pain management. Results: A total of 1042 cancer outpatients were included in the study. The analysis revealed that 42.9% of patients with pain did not receive adequate pain management based on PMI values. Among patients with pain or taking analgesics and referred to palliative or curative RT, 72% and 75% had inadequate or ineffective analgesic therapy, respectively. The odds of receiving adequate pain management (PMI ≥ 0) were higher in patients undergoing palliative RT (OR 2.52; p < 0.001), with worse ECOG-PS scores of 2, 3 and 4 (OR 1.63, 2.23, 5.31, respectively; p: 0.017, 0.002, 0.009, respectively) compared to a score of 1 for those with cancer-related pain (OR 0.38; p < 0.001), and treated in northern Italy compared to central and southern of Italy (OR 0.25, 0.42, respectively; p < 0.001). Conclusions: In this study, a substantial proportion of cancer patients referred to RT departments did not receive adequate pain management. Educational and organizational strategies are necessary to address the inadequate pain management observed in this population. Moreover, increasing the attention paid to non-cancer pain and an earlier referral of patients for palliative RT in the course of the disease may improve pain response and treatment outcomes. Full article
(This article belongs to the Special Issue Palliative Radiotherapy in Cancer)
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