From Bench to Bedside in the Management of Cholangiocarcinoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 2 July 2024 | Viewed by 1835

Special Issue Editors


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Guest Editor
1. Department of Internal Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2. Department of Gastroenterology, “Prof. Dr. O. Fodor” Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
Interests: liver tumors; contrast-enhanced ultrasonography; ultrasound-guided interventional procedures; percutaneous ablation of liver tumors; precision medicine in liver cancer

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Guest Editor
1. Department of Surgery, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2. Department of Surgery, “Prof. Dr. O. Fodor” Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
Interests: liver surgery; liver tumors; cholangiocarcinoma; hepatobiliary surgery

Special Issue Information

Dear Colleagues,

Cholangiocarcinoma (CCA) is a relatively rare tumor arising from the biliary tract epithelium. Deeply heterogeneous in morphology, location, and clinical impact, CCA’s incidence and mortality have progressively increased in the past decades, with little progress on the therapeutic end, leading to a dismally low incidence-to-mortality ratio. Given the recent surge in research on CCA, the Special Ossue aims to cover the currently most challenging topics, ranging from basic and translational research to diagnosis, therapy, and management of advanced disease. The current issue is focused on bench-to-bedside translation and clinical applicability of the matters analyzed, aiming to expand on topics such as challenges in the diagnosis of perihilar CCA, the role of contrast-enhanced ultrasonography in the diagnosis of intrahepatic CCA, the challenges of borderline resectability in surgical management, the role of locoregional therapy in intrahepatic CCA, the potential advent of novel systemic therapies, or the management of challenges in advanced cholangiocarcinoma.

Prof. Dr. Zeno Adrian Spârchez
Prof. Dr. Nadim Al-Hajjar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cholangiocarcinoma
  • non-invasive diagnosis
  • locoregional therapies
  • contrast-enhanced ultrasonography
  • hepatobiliary surgery

Published Papers (1 paper)

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Review

30 pages, 1859 KiB  
Review
Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy
by Manuel Scimeca, Valentina Rovella, Valeria Palumbo, Maria Paola Scioli, Rita Bonfiglio, TOR CENTRE, Gerry Melino, Mauro Piacentini, Luigi Frati, Massimiliano Agostini, Eleonora Candi and Alessandro Mauriello
Cancers 2023, 15(14), 3638; https://doi.org/10.3390/cancers15143638 - 15 Jul 2023
Cited by 1 | Viewed by 1586
Abstract
Cholangiocarcinoma is a highly aggressive cancer arising from the bile ducts. The limited effectiveness of conventional therapies has prompted the search for new approaches to target this disease. Recent evidence suggests that distinct programmed cell death mechanisms, namely, apoptosis, ferroptosis, pyroptosis and necroptosis, [...] Read more.
Cholangiocarcinoma is a highly aggressive cancer arising from the bile ducts. The limited effectiveness of conventional therapies has prompted the search for new approaches to target this disease. Recent evidence suggests that distinct programmed cell death mechanisms, namely, apoptosis, ferroptosis, pyroptosis and necroptosis, play a critical role in the development and progression of cholangiocarcinoma. This review aims to summarize the current knowledge on the role of programmed cell death in cholangiocarcinoma and its potential implications for the development of novel therapies. Several studies have shown that the dysregulation of apoptotic signaling pathways contributes to cholangiocarcinoma tumorigenesis and resistance to treatment. Similarly, ferroptosis, pyroptosis and necroptosis, which are pro-inflammatory forms of cell death, have been implicated in promoting immune cell recruitment and activation, thus enhancing the antitumor immune response. Moreover, recent studies have suggested that targeting cell death pathways could sensitize cholangiocarcinoma cells to chemotherapy and immunotherapy. In conclusion, programmed cell death represents a relevant molecular mechanism of pathogenesis in cholangiocarcinoma, and further research is needed to fully elucidate the underlying details and possibly identify therapeutic strategies. Full article
(This article belongs to the Special Issue From Bench to Bedside in the Management of Cholangiocarcinoma)
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