Molecular Markers and Targeted Therapy for Hepatobiliary Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2180

Special Issue Editor


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Guest Editor
Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Hokkaido, Japan
Interests: photoimmunotherapy; endoscopy; biliary tract cancer; pancreatic cancer; pancreatitis; acute pancreatitis model; mesenchymal stem cells

Special Issue Information

Dear Colleagues,

The poor prognoses of hepatobiliary malignancies such as cholangiocarcinoma and hepatocellular carcinoma, with 5-year relative survival rates of about 20%, are attributed to their difficult early detection and fewer curative, less-invasive anticancer therapies. Recently, some molecular markers for them have been reported, using new technologies such as liquid biopsy, organoids, exosome isolation, and single cell analysis. Based on these, several targeted therapies have also been reported in preclinical and clinical settings. Furthermore, appropriate molecular markers for assessing the efficacy of anti-cancer therapies are also required in order to maximize and manage therapies and improve the prognosis.

This Special Issue aims to publish research related to cutting-edge/preclinical molecular markers for diagnosis or treatment assessment and targeted therapies for hepatobiliary malignancies. Consequently, the development of future research leading to improvements of clinical outcomes is anticipated.

We are pleased to invite you to submit articles on the above-mentioned topics. In this Special Issue, original research articles and reviews are welcome. Research areas may include the following: molecular biology; pathology; genetics; organoids; exosome; chemotherapy; and phototherapy.

I look forward to receiving your contributions.

Dr. Masaki Kuwatani
Guest Editor

Manuscript Submission Information

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Keywords

  • cholangiocarcinoma
  • hepatocellular carcinoma
  • molecule
  • gene
  • chemotherapy
  • phototherapy

Published Papers (2 papers)

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Review

21 pages, 2238 KiB  
Review
Locoregional Therapies for Hepatobiliary Tumors: Contemporary Strategies and Novel Applications
by Andrei M. Jipa and Mina S. Makary
Cancers 2024, 16(7), 1271; https://doi.org/10.3390/cancers16071271 - 25 Mar 2024
Viewed by 521
Abstract
A large majority of primary hepatobiliary tumors are hepatocellular carcinomas (HCC), with the remainer being cholangiocarcinoma. While surgical resection remains the gold standard treatment for hepatobiliary tumors, relatively few patients are operative candidates, and systemic treatments have limited effectiveness. Locoregional therapies offer significant [...] Read more.
A large majority of primary hepatobiliary tumors are hepatocellular carcinomas (HCC), with the remainer being cholangiocarcinoma. While surgical resection remains the gold standard treatment for hepatobiliary tumors, relatively few patients are operative candidates, and systemic treatments have limited effectiveness. Locoregional therapies offer significant promise in the management of HCC. Ablation and radioembolization may offer similar outcomes to surgery for early-stage hepatocellular carcinoma while radioembolization and chemoembolization are valuable in the management of advanced disease. There is significantly less evidence for the role of locoregional therapy in the treatment of cholangiocarcinoma, although it appears to be well tolerated. Full article
(This article belongs to the Special Issue Molecular Markers and Targeted Therapy for Hepatobiliary Tumors)
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16 pages, 286 KiB  
Review
Current Status of Targeted Therapy for Biliary Tract Cancer in the Era of Precision Medicine
by Takafumi Mie, Takashi Sasaki, Takeshi Okamoto, Takaaki Furukawa, Tsuyoshi Takeda, Akiyoshi Kasuga, Masato Ozaka and Naoki Sasahira
Cancers 2024, 16(5), 879; https://doi.org/10.3390/cancers16050879 - 22 Feb 2024
Viewed by 1263
Abstract
First-line chemotherapy has been established for advanced biliary tract cancer (BTC). However, few treatment options are available as second-line treatment. Advances in comprehensive genomic analysis revealed that nearly half of patients with BTC harbor targetable genetic alterations such as fibroblast growth factor receptor [...] Read more.
First-line chemotherapy has been established for advanced biliary tract cancer (BTC). However, few treatment options are available as second-line treatment. Advances in comprehensive genomic analysis revealed that nearly half of patients with BTC harbor targetable genetic alterations such as fibroblast growth factor receptor (FGFR), isocitrate dehydrogenase (IDH), BRAF, human epidermal growth factor receptor 2 (HER2), microsatellite instability (MSI)-high, neurotrophic tropomyosin receptor kinase (NTRK), rearranged during transfection (RET), and poly (adenosine diphosphate-ribose) polymerase (PARP). This review summarizes currently available options in precision medicine and clinical trials for patients with advanced BTC. Full article
(This article belongs to the Special Issue Molecular Markers and Targeted Therapy for Hepatobiliary Tumors)
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