Radiation Therapy for Modern Management of Bone Metastases

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 674

Special Issue Editor


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Guest Editor
Department of Diagnostic Imaging, Oncological Radiotherapy, and Hematology, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, 00168 Roma, Italy
Interests: gastrointestinal cancer; genitourinary tract cancer; technology advances in radiation oncology; MRI-guided-radiation oncology; lung cancer; breast cancer; precision radiotherapy

Special Issue Information

Dear Colleagues,

Bone metastases (BM) frequently occur during malignant disease. The incidence of BM is expected to rise in the future due to an increase in the survival rates of patients with cancer. Radiotherapy (RT) is a crucial part of the management of BM. RT can efficiently relieve pain and improve the quality of life of patients, thus forming a crucial part of palliative care in general. Moreover, recent insights suggest a clear effect on the improvement of the disease and overall survival by locally controlling single metastases, along with the administration of systemic therapies (thus including the ablative approach aiming for local control of BM) in oligometastatic settings. Finally, RT can play a role in improving the systemic effect of immune oncological therapy by the local treatment of lesions, including BM.

The clinical indications, the prescriptive optimal dose for each clinical sub-setting and different aim (e.g., palliation, local ablation and immune reaction stimulation), the target delineations and many other factors are still unclear, which makes investigating these issues an urgent challenge for modern oncologists and radiation oncologists in particular. Our Special Issue will deal these issues in this research field.

Dr. Francesco Cellini
Guest Editor

Manuscript Submission Information

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Keywords

  • radiotherapy
  • palliative care
  • steretactic radiotherapy
  • SBRT
  • immunotherapy
  • chemotherapy
  • oligometastases

Published Papers (1 paper)

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Research

15 pages, 7695 KiB  
Article
Treatment of Pelvic and Spinal Bone Metastases: Radiotherapy and Hyperthermia Alone vs. in Combination
by Jong-Hun Kim, Jin-Yong Shin and Sun-Young Lee
Cancers 2024, 16(8), 1604; https://doi.org/10.3390/cancers16081604 - 22 Apr 2024
Viewed by 284
Abstract
Painful pelvic and spinal bone metastases are a considerable challenge for doctors and patients. Conventional therapies include morphine-equivalent medication (MeM) and local radiotherapy (RT), but these interventions are not always successful. More recently, hyperthermia (HT) has been applied to complement RT and MeM, [...] Read more.
Painful pelvic and spinal bone metastases are a considerable challenge for doctors and patients. Conventional therapies include morphine-equivalent medication (MeM) and local radiotherapy (RT), but these interventions are not always successful. More recently, hyperthermia (HT) has been applied to complement RT and MeM, and this complex approach has shown promising synergistic results. The objective of our study was to present the results of RT combined with a special kind of HT (modulated electrohyperthermia, mEHT), in which some of the thermal effect is contributed by equivalent nonthermal components, drastically reducing the necessary power and energy. This retrospective study included 61 patients divided into three groups with pelvic and spinal bone metastases to compare the effects of RT and mEHT alone and in combination (RT + mEHT). A detailed evaluation of pain intensity, measured by the brief pain inventory score, MeM use, and breakthrough pain episodes, revealed no significant differences between RT and mEHT alone; thus, these individual methods were considered equivalent. However, RT + mEHT yielded significantly better results in terms of the above parameters. Clinically, mEHT has a lower risk of adverse thermal effects, and due to its efficacy, mEHT can be used to treat RT-resistant lesions. Full article
(This article belongs to the Special Issue Radiation Therapy for Modern Management of Bone Metastases)
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