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Cancers
Special Issues
Advances in the Diagnosis and Treatment of Genitourinary Cancers
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Advances in the Diagnosis and Treatment of Genitourinary Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 10 May 2024 | Viewed by 2032

Special Issue Editors

Prof. Dr. Piotr Radziszewski

E-Mail Website
Guest Editor
Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland
Interests: genitourinary cancer; urology oncology; point of care diagnostics; personalized treatment; immunotherapy
Dr. Łukasz Zapała

E-Mail Website
Guest Editor
Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Warsaw, Poland
Interests: genitourinary cancer; point of care diagnostics; personalized treatment; immunotherapy

Special Issue Information

Dear Colleagues,

Genitourinary cancers are diseases affecting an increasingly greater number of people, the diagnosis and treatment of which are currently undergoing fast and sometimes dramatic changes due to the current landscape of suboptimal management of these diseases. A characteristic feature of urological cancer treatment is the significant heterogeneity of patients (including different stages of local advancement, different locations of metastases, the heterogeneity of pathological findings, etc.). Therefore, predicting the response to modern treatments remains the unmet need of modern urologic oncology, and new diagnostic methods, including but not limited to point-of-care diagnostics, represent a challenge to current  guidelines and require verification. Additionally, further development awaits us as far as sufficient neoadjuvant and adjuvant treatment in the perioperative setting is concerned. However, recent advancements in systematic treatment, i.e., immunotherapy, have shed light on new treatment paradigms to be implemented in various clinical scenarios, including localized disease, and recent progress in minimally invasive surgical techniques has lead to revisions to the treatment of many urological tumors.

This Special Issue aims to cover these novel approaches in genitourinary cancers. We look forward to receiving your original papers and reviews related to advances in the treatment of male genitourinary cancers.

Prof. Dr. Piotr Radziszewski
Dr. Łukasz Zapała
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genitourinary cancer
  • point-of-care diagnostics
  • personalized treatment
  • immunotherapy
  • treatment

Published Papers (2 papers)

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Research

11 pages, 17733 KiB  
Article
Prognostic Significance of the Cribriform Pattern in Prostate Cancer: Clinical Outcomes and Genomic Alterations
by Mutlay Sayan, Yetkin Tuac, Mahmut Akgul, Grace K. Pratt, Mary D. Rowan, Dilara Akbulut, Samet Kucukcolak, Elza Tjio, Shalini Moningi, Jonathan E. Leeman, Peter F. Orio, Paul L. Nguyen, Anthony V. D’Amico and Cagdas Aktan
Cancers 2024, 16(7), 1248; https://doi.org/10.3390/cancers16071248 - 22 Mar 2024
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Abstract
Purpose: Given the diverse clinical progression of prostate cancer (PC) and the evolving significance of histopathological factors in its management, this study aimed to explore the impact of cribriform pattern 4 (CP4) on clinical outcomes in PC patients and examine its molecular characteristics. [...] Read more.
Purpose: Given the diverse clinical progression of prostate cancer (PC) and the evolving significance of histopathological factors in its management, this study aimed to explore the impact of cribriform pattern 4 (CP4) on clinical outcomes in PC patients and examine its molecular characteristics. Methods: This retrospective study analyzed data from The Cancer Genome Atlas (TCGA) database and included PC patients who underwent radical prostatectomy (RP) and had pathology slides available for the assessment of CP4. A multivariable competing risk regression analysis was used to assess the association between CP4 and progression-free survival (PFS) while adjusting for established PC prognostic factors. The frequency of genomic alterations was compared between patients with and without CP4 using the Fisher’s exact test. Results: Among the 394 patients analyzed, 129 (32.74%) had CP4. After a median follow-up of 40.50 months (IQR: 23.90, 65.60), the presence of CP4 was significantly associated with lower PFS (AHR, 1.84; 95% CI, 1.08 to 3.114; p = 0.023) after adjusting for covariates. Seven hub genes—KRT13, KRT5, KRT15, COL17A1, KRT14, KRT16, and TP63—had significantly lower mRNA expression levels in patients with CP4 compared to those without. Conclusions: PC patients with CP4 have distinct genomic alterations and are at a high risk of disease progression following RP. Therefore, these patients may benefit from additional post-RP treatments and should be the subject of a prospective randomized clinical trial. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Treatment of Genitourinary Cancers)
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15 pages, 10387 KiB  
Article
Urinary Microbiome Dysbiosis and Immune Dysregulations as Potential Diagnostic Indicators of Bladder Cancer
by Matthew Uzelac, Ruomin Xin, Tianyi Chen, Daniel John, Wei Tse Li, Mahadevan Rajasekaran and Weg M. Ongkeko
Cancers 2024, 16(2), 394; https://doi.org/10.3390/cancers16020394 - 17 Jan 2024
Viewed by 948
Abstract
There are a total of 82,290 new cases and 16,710 deaths estimated for bladder cancer in the United States in 2023. Currently, urine cytology tests are widely used for bladder cancer diagnosis, though they suffer from variable sensitivity, ranging from 45 to 97%. [...] Read more.
There are a total of 82,290 new cases and 16,710 deaths estimated for bladder cancer in the United States in 2023. Currently, urine cytology tests are widely used for bladder cancer diagnosis, though they suffer from variable sensitivity, ranging from 45 to 97%. More recently, the microbiome has become increasingly recognized for its role in human diseases, including cancers. This study attempts to characterize urinary microbiome bladder cancer-specific dysbiosis to explore its diagnostic potential. RNA-sequencing data of urine samples from patients with bladder cancer (n = 18) and matched controls (n = 12) were mapped to bacterial sequences to yield species-level abundance approximations. Urine samples were analyzed at both the population and species level to reveal dysbiosis associated with bladder cancer. A panel of 35 differentially abundant species was discovered, which may be useful as urinary biomarkers for this disease. We further assessed whether these species were of similar significance in a validation dataset (n = 81), revealing that the genera Escherichia, Acinetobacter, and Enterobacter were consistently differentially abundant. We discovered distinct patterns of microbial-associated immune modulation in these samples. Several immune pathways were found to be significantly enriched with respect to the abundance of these species, including antigen processing and presentation, cytosolic DNA sensing, and leukocyte transendothelial migration. Differential cytokine activity was similarly observed, suggesting the urinary microbiome’s correlation to immune modulation. The adherens junction and WNT signaling pathways, both implicated in the development and progression of bladder cancer, were also enriched with these species. Our findings indicate that the urinary microbiome may reflect both microbial and immune dysregulations of the tumor microenvironment in bladder cancer. Given the potential biomarker species identified, the urinary microbiome may provide a non-invasive, more sensitive, and more specific diagnostic tool, allowing for the earlier diagnosis of patients with bladder cancer. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Treatment of Genitourinary Cancers)
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