Clear Cell Renal Cell Carcinoma 2024–2025
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 199
Special Issue Editors
Interests: translational uropathology; pathological diagnosis; basic fundamentals of tumor biology
Special Issues, Collections and Topics in MDPI journals
Interests: urogenital and neurosurgical pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Clear cell renal cell carcinoma is one of the most interesting areas of study in oncology right now. Despite recent advances, these tumors continue to present a health problem of major concern in Western societies, seriously affecting public health services. The characteristics of this tumor make it an exciting field for translational collaboration between clinicians and basic researchers.
Clear cell renal cell carcinoma is a paradigmatic example of inter- and intra-tumor heterogeneity from morphological, immunohistochemical, and molecular viewpoints. It is also a model of hypoxia-related carcinogenesis. The latest findings on the spatial and temporal evolutionary patterns detected in this tumor are opening up possibilities for more successful treatments. In addition, the identification of metastatic phenotypes will allow for the early detection of aggressive genotypes, guiding specific patient management.
This tumor presents an excellent model for investigating the complexity of tumor/tumor and tumor/environment relationships from an ecological perspective. Analyzing internal tumor self-organization through the specialization of cell clones and subclones as local invaders and metastasizes, on one hand, and the interactions of specific subsets of tumor cells with the local host microenvironment, on the other, will significantly enrich our knowledge of this neoplasm. Finally, alternative approaches such as game theory have provided, in recent years, promising mathematical models that can be used to unveil the diversity of possible behaviors of this polyedrical disease.
Clear cell renal cell carcinoma also encompasses a paradigmatic test bench for antiangiogenic and immune checkpoint blockage therapies. The refinement of these therapeutic tools administered alone or in combination is a hot issue in oncology, and several international trials are underway in this area.
This Special Issue intends to serve as a multidisciplinary platform where urologists, oncologists, pathologists, radiologists, and basic researchers interested in clear cell renal cell carcinoma may meet and collaborate.
Dr. José I. López
Dr. Claudia Manini
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- clear cell renal cell carcinoma
- pathology
- diagnosis
- hypoxia
- intratumor heterogeneity
- immune checkpoint blockage antiangiogenic therapy
