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Cancers
Special Issues
Molecular Biology, Diagnosis and Management of Endometrial Cancer
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Molecular Biology, Diagnosis and Management of Endometrial Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 12 July 2025 | Viewed by 2060

Special Issue Editors

Dr. Georgios Androutsopoulos

E-Mail Website
Guest Editor
Gynaecological Oncology Unit, Department of Obstetrics & Gynaecology School of Medicine, University of Patras, Patras, Greece
Interests: obstetrics—gynaecology; gynaecological oncology
Special Issues, Collections and Topics in MDPI journals
Dr. Georgios Michail

E-Mail Website
Guest Editor
Department of Obstetrics & Gynaecology, School of Medicine, University of Patras, Patras, Greece
Interests: obstetrics—gynaecology; gynaecological oncology; cervical pathology
Special Issues, Collections and Topics in MDPI journals
Dr. Thomas Vrekoussis

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Medical School, University Hospital of Crete, 715 00 Heraklion, Greece
Interests: obstetrics—gynaecology; gynaecological oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometrial cancer (EC) is the second most common malignancy of the female reproductive system. The main aim of this Special Issue is to present recent advances in the molecular biology, diagnosis and management of EC.

In the past, the sporadic classification of EC cases was based on clinical, metabolic, endocrine and pathological features. More recently, genomic data were used for an updated EC classification, reflecting the increased impact of molecular biology in disease progression and patients’ outcome.

It is widely accepted that systematic surgical staging represents the method of primary EC treatment. Pelvic and para-aortic lymphadenectomy remains an essential part of systematic surgical staging and provides meaningful data regarding the necessity of postoperative adjuvant treatment. Sentinel lymph node mapping and dissection epitomizes an equilibrium between systematic lymphadenectomy and the absence of lymphadenectomy in well-selected EC patients of low and intermediate risk. The non-surgical fertility-sparing approach can be offered only in well-defined subgroups of young EC patients with early-stage disease, a strong desire for fertility preservation and detailed counselling.

In conclusion, the early diagnosis and appropriate therapeutic management of EC patients have a direct effect on patients’ quality of life and overall survival. Moreover, the extent of surgical staging and the type of postoperative adjuvant treatment should be thoroughly individualized on the basis of EC type, disease stage, fertility issues and patient’s general performance status.

Potential topics include, but are not limited to:

  • Preoperative evaluation
  • Molecular biology
  • Systematic surgical staging
  • Pelvic and paraaortic lymph node dissection
  • Sentinel lymph node mapping and dissection
  • Systemic therapy
  • Radiotherapy
  • Fertility preservation
  • Molecular targeted therapies

Dr. Georgios Androutsopoulos
Dr. Georgios Michail
Dr. Thomas Vrekoussis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometrial cancer
  • molecular biology
  • lymph node dissection
  • sentinel lymph node mapping
  • sentinel lymph node dissection
  • surgery
  • systemic therapy
  • radiotherapy
  • fertility preservation
  • molecular targeted therapies

Published Papers (2 papers)

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21 pages, 1247 KiB  
Article
Disease-Free and Overall Survival Implications of Pelvic Lymphadenectomy in Endometrial Cancer: A Retrospective Population-Based Single-Center Study
by Marcin Misiek, Kaja Michalczyk, Aleksandra Kukla-Jakubowska, Marcin Lewandowski, Agnieszka Wrona-Cyranowska, Magdalena Koźmińska, Piotr Fras and Anita Chudecka-Głaz
Cancers 2023, 15(23), 5636; https://doi.org/10.3390/cancers15235636 - 29 Nov 2023
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Abstract
The role of pelvic lymphadenectomy in endometrial cancer remains unclear. In this study, we aimed to investigate the influence of lymphadenectomy on progression-free and overall survival among patients diagnosed with endometrial carcinoma. This retrospective single-center study included 1532 patients operated on in a [...] Read more.
The role of pelvic lymphadenectomy in endometrial cancer remains unclear. In this study, we aimed to investigate the influence of lymphadenectomy on progression-free and overall survival among patients diagnosed with endometrial carcinoma. This retrospective single-center study included 1532 patients operated on in a Polish reference center for gynecologic oncology at Holy Cross Hospital, Kielce, between 2002 and 2020. A total of 1004 patients underwent systematic lymphadenectomy as a part of their surgical procedure. The median number of collected lymph nodes was seven. In total, 11.6% of patients were found to have lymph node invasion. The number of lymph nodes removed correlated with patient survival. In patients in whom the number of removed lymph nodes was above the median (>7), the risk of death was reduced (HR 0.68, p = 0.002). The risk of death correlated with the presence of lymph node metastasis (HR 4.12, p < 0.001). The risk of cancer progression was associated with the number of lymph nodes removed (HR 0.54, p = 0.006), and the risk of EC recurrence was greater in patients with lymph node metastasis (HR 1.94, p = 0.016). Our study provides additional evidence that systematic lymphadenectomy may influence the disease-free and overall survival of patients with endometrial cancer. The number of lymph nodes removed correlated with patient prognosis. Further studies are needed to evaluate the use of lymphadenectomy in endometrial cancer treatment. Full article
(This article belongs to the Special Issue Molecular Biology, Diagnosis and Management of Endometrial Cancer)
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Review

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20 pages, 1457 KiB  
Review
Characteristics of Cancer Stem Cells and Their Potential Role in Endometrial Cancer
by Karolina Frąszczak and Bartłomiej Barczyński
Cancers 2024, 16(6), 1083; https://doi.org/10.3390/cancers16061083 - 07 Mar 2024
Viewed by 887
Abstract
Endometrial cancer is one of most common types of gynaecological tumours in developing countries. It has been suggested that cancer stem cells play an important role in the development of endometrial cancer. These are a subset of highly tumorigenic cells with similar features [...] Read more.
Endometrial cancer is one of most common types of gynaecological tumours in developing countries. It has been suggested that cancer stem cells play an important role in the development of endometrial cancer. These are a subset of highly tumorigenic cells with similar features to normal stem cells (unlimited proliferation, multi-potential differentiation, self-renewal, aggressiveness, invasion, recurrence, and chemo- and endocrine therapy resistance). Wnt/β-catenin, Hedghog, and Notch1 are the most frequently activated pathways in endometrial cancer stem cells. The presence of cancer stem cells is associated with the resistance to chemotherapy caused by different mechanisms. Various markers, including CD24, CD40, CD44, CD9, CD133, and CD 166, have been identified on the surface of these cells. A higher expression of such markers translates into enhanced tumorigenicity. However, there is no strong evidence showing that any of these identified markers can be used as the universal marker for endometrial cancer stem cells. Growing data from genomic and proteomic profiling shed some light on the understanding of the molecular basis of cancers in humans and the role of cancer stem cells. However, there is much left to discover. Therefore, more studies are needed to fully uncover their functional mechanisms in order to prevent the development and recurrence of cancer, as well as to enhance treatment effectiveness. Full article
(This article belongs to the Special Issue Molecular Biology, Diagnosis and Management of Endometrial Cancer)
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