Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
5.2
Journals
Cancers
Special Issues
Circadian Rhythms, Cancers and Chronotherapy
share announcement

Circadian Rhythms, Cancers and Chronotherapy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 2214

Special Issue Editors

Prof. Dr. Francis Levi

E-Mail Website
Guest Editor
1. UPR “Chronotherapy, Cancer and Transplantation”, Medical School, Paris-Saclay University, 94800 Villejuif, France
2. Cancer Chronotherapy Team, Cancer Research Centre, Division of Biomedical Sciences, Warwick Medical School, Coventry CV4 7AL, UK
3. Centre Hépato Biliaire, AP-HP, Hôpital Paul Brousse (APHP), 94800 Villejuif, France
Interests: circadian clocks; biological rhythms; chronopharmacology; chronotherapy; gastro-intestinal oncology; biomakers; digital health
Dr. Pasquale F. Innominato

E-Mail Website
Guest Editor
1. Oncology Department, Ysbyty Gwynedd, Betsi Cadwaladr University Health Board, Bangor LL57 2PW, UK
2. Cancer Research Centre, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
3. UPR “Chronotherapy, Cancers and Transplantation”, Faculty of Medicine, Paris-Saclay University, 94800 Villejuif, France
Interests: cancer chronotherapeutics; circadian rhythms; supportive care; digital health
Dr. Esra Tasali

E-Mail Website
Guest Editor
Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Interests: sleep and circadian rhythms; sleep disorders; energy metabolism

Special Issue Information

Dear Colleagues,

This Special Issue on “Circadian rhythms, Cancers and Chronotherapy” aims at advancing precision and personalized cancer medicine. Toward such goal, we are pleased to invite you to submit original or review scientific or biomedical articles on these topics. We welcome original contributions reporting new challenging scientific results and/or highlighting novel approaches regarding the molecular, cellular, and physiologic interactions between circadian rhythms and cancer processes and treatments, as well as their healthcare implications. Indeed, a hierarchical network of cellular clocks, consisting of a system of 15 clock genes, orchestrates cellular metabolism, proliferation, and survival, as well as physiology and responses to therapeutic agents, over a 24 h timescale. Accumulating evidence supports an important role of circadian rhythms both for carcinogenesis processes from initiation to progression and metastasis, and for the tolerability and efficacy of all kinds of cancer treatments. However, circadian rhythms can differ as a function of sex, age, environment, genetics, or other biological factors in experimental cancer models, among people at risk of cancer, and among cancer patients. Manuscripts on the relevance of circadian or other biological clocks in the following research areas may include (but are not limited to):

  • In vitro and in vivo experimental cancer models
  • Drug development and chronotherapy
  • Chemotherapy, immunotherapy, targeted agents, radiotherapy, surgery
  • Circadian host or tumor biomarkers
  • Electronic patient-reported outcomes
  • Circadian rhythms and sleep
  • Sex- and age specificities
  • Clinical trial designs
  • Mathematical models and artificial intelligence
  • Digital healthcare, telemedicine, logistics

We look forward to receiving your contributions.

Prof. Dr. Francis Levi
Dr. Pasquale F. Innominato
Dr. Esra Tasali
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • circadian rhythms
  • clock genes
  • carcinogenesis
  • chronotherapy, biomarkers
  • patient-reported outcomes
  • sleep
  • sex
  • precision oncology
  • artificial intelligence

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 13335 KiB  
Article
Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice
by Manasi Das, Deepak Kumar, Consuelo Sauceda, Alexis Oberg, Lesley G. Ellies, Liping Zeng, Lily J. Jih, Isabel G. Newton and Nicholas J. G. Webster
Cancers 2024, 16(8), 1513; https://doi.org/10.3390/cancers16081513 - 16 Apr 2024
Viewed by 563
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) has surpassed the hepatitis B virus and hepatitis C virus as the leading cause of chronic liver disease in most parts of the Western world. MASLD (formerly known as NAFLD) encompasses both simple steatosis and more aggressive [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has surpassed the hepatitis B virus and hepatitis C virus as the leading cause of chronic liver disease in most parts of the Western world. MASLD (formerly known as NAFLD) encompasses both simple steatosis and more aggressive metabolic dysfunction-associated steatohepatitis (MASH), which is accompanied by inflammation, fibrosis, and cirrhosis, and ultimately can lead to hepatocellular carcinoma (HCC). There are currently very few approved therapies for MASH. Weight loss strategies such as caloric restriction can ameliorate the harmful metabolic effect of MASH and inhibit HCC; however, it is difficult to implement and maintain in daily life, especially in individuals diagnosed with HCC. In this study, we tested a time-restricted feeding (TRF) nutritional intervention in mouse models of MASH and HCC. We show that TRF abrogated metabolic dysregulation induced by a Western diet without any calorie restriction or weight loss. TRF improved insulin sensitivity and reduced hyperinsulinemia, liver steatosis, inflammation, and fibrosis. Importantly, TRF inhibited liver tumors in two mouse models of obesity-driven HCC. Our data suggest that TRF is likely to be effective in abrogating MASH and HCC and warrant further studies of time-restricted eating in humans with MASH who are at higher risk of developing HCC. Full article
(This article belongs to the Special Issue Circadian Rhythms, Cancers and Chronotherapy)
►▼ Show Figures

Figure 1

14 pages, 275 KiB  
Article
Rotating Night Shift Work, Sleep, and Thyroid Cancer Risk in the Nurses’ Health Study 2
by Kyriaki Papantoniou, Peter Konrad, Shahab Haghayegh, Susanne Strohmaier, A. Heather Eliassen and Eva Schernhammer
Cancers 2023, 15(23), 5673; https://doi.org/10.3390/cancers15235673 - 30 Nov 2023
Cited by 1 | Viewed by 1116
Abstract
Night shift work has been associated with breast, prostate, and colorectal cancer, but evidence on other types of cancer is limited. We prospectively evaluated the association of rotating night shift work, sleep duration, and sleep difficulty with thyroid cancer risk in the Nurses’ [...] Read more.
Night shift work has been associated with breast, prostate, and colorectal cancer, but evidence on other types of cancer is limited. We prospectively evaluated the association of rotating night shift work, sleep duration, and sleep difficulty with thyroid cancer risk in the Nurses’ Health Study 2 (NHS2). We assessed rotating night shift work duration (years) at baseline and throughout follow-up (1989–2015) and sleep characteristics in 2001. Cox proportional hazard models, adjusted for potential confounders, were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for (a) shift work duration, (b) sleep duration, and (c) difficulty falling or staying asleep. We stratified the analyses of night shift work by sleep duration and sleep difficulty. Over 26 years of follow-up, 588 incident cases were identified among 114,534 women in the NHS2 cohort. We observed no association between night shift work and the risk of thyroid cancer. Difficulty falling or staying asleep was suggestively associated with a higher incidence of thyroid cancer when reported sometimes (HR 1.26, 95% CI 0.95, 1.66) and all or most of the time (HR 1.35, 95% CI 1.00, 1.81). Night shift workers (10+ years) with sleep difficulty all or most of the time (HR 1.47; 0.58–3.73) or with >7 h of sleep duration (HR 2.17; 95% CI, 1.21–3.92) had a higher risk of thyroid cancer. We found modest evidence for an increased risk of thyroid cancer in relation to sleep difficulty, which was more pronounced among night shift workers. Full article
(This article belongs to the Special Issue Circadian Rhythms, Cancers and Chronotherapy)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop