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Cancers
Special Issues
EVs and EPS in Cancer: Cell-to-Cell Communication, Diagnosis, and Evaluation...
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EVs and EPS in Cancer: Cell-to-Cell Communication, Diagnosis, and Evaluation of Cancer Therapy Response

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 1338

Special Issue Editors

Prof. Dr. Irina Nazarenko

E-Mail Website
Guest Editor
Institute for Infection Prevention and Hospital Epidemiology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Interests: extracellular vesicles; EV
Dr. José Antonio López-Guerrero

E-Mail Website
Guest Editor
Head of the Laboratory of Molecular Biology Scientific Manager of the Biobank, Fundación Instituto Valenciano de Oncología, C/Prof. Beltrán Báguena, 8-11, 46009 Valencia, Spain
Interests: genetics; biomarkers; prostate cancer; gynecological cancer; sarcoma; biobanking; breast cancer; molecular pathology; extracellular vesicles

Special Issue Information

Dear Colleagues,

Extracellular vesicles (EVs) and Particles (EPs) play essential roles in intercellular signaling in cancers. Interest in EVs increased dramatically after the discovery that EVs could transfer nucleic acids like RNA from cell to cell. Associated with EVs from certain cells or tissues, nucleic acids could be easily amplified as markers of tumor cells. When EVs are taken up by other cells, they may alter the behavior of the recipient cell. Thus, EVs are of importance in forming tumor landscapes.

This Special Issue is aimed at understanding not only EV-based cell-to-cell communication in cancers but also EVs and EPs in the diagnosis of cancers and evaluation of the therapy response. Topics of interest may range from the
application of EVs in liquid biopsy to the latest technology and discovery of EVs to characterize cancer cells. Original research papers and review articles in related fields are welcomed.

Prof. Dr. Irina Nazarenko
Dr. José Antonio López-Guerrero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles
  • EVs
  • particles
  • cancer
  • liquid biopsy
  • cell-cell communication

Published Papers (1 paper)

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Review

24 pages, 2498 KiB  
Review
Emerging Roles of Small Extracellular Vesicles in Gastrointestinal Cancer Research and Therapy
by Nora Schneider, Patrick Christian Hermann, Tim Eiseler and Thomas Seufferlein
Cancers 2024, 16(3), 567; https://doi.org/10.3390/cancers16030567 - 29 Jan 2024
Viewed by 1126
Abstract
Discovered in the late eighties, sEVs are small extracellular nanovesicles (30–150 nm diameter) that gained increasing attention due to their profound roles in cancer, immunology, and therapeutic approaches. They were initially described as cellular waste bins; however, in recent years, sEVs have become [...] Read more.
Discovered in the late eighties, sEVs are small extracellular nanovesicles (30–150 nm diameter) that gained increasing attention due to their profound roles in cancer, immunology, and therapeutic approaches. They were initially described as cellular waste bins; however, in recent years, sEVs have become known as important mediators of intercellular communication. They are secreted from cells in substantial amounts and exert their influence on recipient cells by signaling through cell surface receptors or transferring cargos, such as proteins, RNAs, miRNAs, or lipids. A key role of sEVs in cancer is immune modulation, as well as pro-invasive signaling and formation of pre-metastatic niches. sEVs are ideal biomarker platforms, and can be engineered as drug carriers or anti-cancer vaccines. Thus, sEVs further provide novel avenues for cancer diagnosis and treatment. This review will focus on the role of sEVs in GI-oncology and delineate their functions in cancer progression, diagnosis, and therapeutic use. Full article
(This article belongs to the Special Issue EVs and EPS in Cancer: Cell-to-Cell Communication, Diagnosis, and Evaluation of Cancer Therapy Response)
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