Current Status and Perspective of Immunotherapy for Head and Neck Squamous Cell Carcinoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1430

Special Issue Editors


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Guest Editor
Centre Hospitalier Universitaire de Bordeaux, 33075 Bordeaux, France
Interests: head and neck cancer; immunotherapy; targeted therapy

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Guest Editor
Department of Otolaryngology Head and Neck Surgery, Technical University Munich, 80333 Munich, Germany
Interests: head and neck cancer (HNSCC); tumorimmunology; immunotherapy; clinical study HNSCC; platelets; platelet-driven cancer progression; toll like receptors and cancer

Special Issue Information

Dear Colleagues,

Head and neck squamous cell carcinoma (HNSCC) is the most frequent cancer of the head and neck.

Immune-checkpoint inhibitors have changed the outcome for some for some patients with recurrent or metastatic HNSCC (R/M HNSCC).

However, most patients with HNSCC present primary or secondary resistance under anti PD1/PD-1. A number of clinical trials have failed to demonstrate efficacy in both locally advanced diseases and in RM HNSCC.

Novel biomarkers and novel strategies for association are needed to increase the efficacy of immunotherapy for head and neck cancer patients, as locally advanced diseases or in the R/M setting.

Therefore, we are looking for manuscripts covering the current status in local diseases or R/M, as well as novel strategies for use immune-checkpoint inhibitors for HNSCC. This Special Issue welcomes the submission of reviews as well as original research articles.

Dr. Amaury Daste
Prof. Dr. Wollenberg Barbara
Guest Editors

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Keywords

  • head and neck cancer
  • immunotherapy
  • molecular pathogenesis
  • tumor biology
  • head and neck squamous cell carcinoma

Published Papers (1 paper)

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Review

20 pages, 639 KiB  
Review
Mechanisms of Resistance and Therapeutic Perspectives in Immunotherapy for Advanced Head and Neck Cancers
by Andrew Meci, Neerav Goyal and Guy Slonimsky
Cancers 2024, 16(4), 703; https://doi.org/10.3390/cancers16040703 - 07 Feb 2024
Viewed by 1088
Abstract
Immunotherapy is emerging as an effective treatment for advanced head and neck cancers and interest in this treatment modality has led to rapid expansion of this research. Pembrolizumab and nivolumab, monoclonal antibodies directed against the programmed cell death-1 (PD-1) receptor, are US Food [...] Read more.
Immunotherapy is emerging as an effective treatment for advanced head and neck cancers and interest in this treatment modality has led to rapid expansion of this research. Pembrolizumab and nivolumab, monoclonal antibodies directed against the programmed cell death-1 (PD-1) receptor, are US Food and Drug Administration (FDA)- and European Medical Agency (EMA)-approved immunotherapies for head and neck squamous cell carcinoma (HNSCC). Resistance to immunotherapy is common, with about 60% of patients with recurrent or metastatic HNSCC not responding to immunotherapy and only 20–30% of patients without disease progression in the long term. Overcoming resistance to immunotherapy is therefore essential for augmenting the effectiveness of immunotherapy in HNSCC. This review details the innate and adaptive mechanisms by which head and neck cancers can become resistant to immunotherapeutic agents, biomarkers that can be used for immunotherapy patient selection, as well as other factors of the tumor microenvironment correlated with therapeutic response and prognosis. Numerous combinations and novel immunotherapies are currently being trialed, based on better understood immune evasion mechanisms. These potential treatments hold the promise of overcoming resistance to immunotherapy in head and neck cancers. Full article
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