Clinical Research and Progress in the Treatment of Breast Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 516

Special Issue Editors


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Guest Editor
Kantonsspital St Gallen, St Gallen, Switzerland
Interests: breast cancer; treatment

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Co-Guest Editor
Kantonsspital St Gallen, St Gallen, Switzerland
Interests: breast cancer; treatment

Special Issue Information

Dear Colleagues,

Clinical research and progress in the treatment of early breast cancer comprise both locoregional treatment and systemic therapy. Locoregional treatment includes the surgery of the breast and the axilla and radiotherapy of the breast or chest wall and regional nodes. Most of the surgical morbidity in the treatment of breast cancer is caused by axilla surgery. Thus, surgical de-escalation strategies investigate reducing axilla surgery, or even disregarding this intervention in patients without a worse locoregional outcome risk. The short-duration radiotherapy of early breast cancer or even omission of radiotherapy in low-risk patients are clinical research issues.

Neoadjuvant therapy in early breast cancer is the standard of care in triple-negative and HER2-positive breast cancer as the adjustment of post-neoadjuvant systemic therapy based on the treatment response to neoadjuvant therapy enables long-term outcome improvements. Multiple translational research projects currently focus on the detection of circulating tumor DNA in early breast cancer indicating a high risk of relapse even though it is still unknown whether early treatment based on the detection of ctDNA may improve outcomes.

The current standard of care and the future developments in locoregional and systemic therapy will be discussed in this Special Issue.

Prof. Dr. Jens Bodo Huober
Dr. Inga Bekes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • early breast cancer
  • de-escalation
  • locoregional treatment
  • axilla surgery
  • radiotherapy
  • neoadjuvant therapy
  • post-neoadjuvant therapy
  • ctDNA  detection

Published Papers (1 paper)

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Review

19 pages, 1076 KiB  
Review
Axillary Surgery for Breast Cancer in 2024
by Martin Heidinger and Walter P. Weber
Cancers 2024, 16(9), 1623; https://doi.org/10.3390/cancers16091623 - 23 Apr 2024
Viewed by 274
Abstract
Axillary surgery for patients with breast cancer (BC) in 2024 is becoming increasingly specific, moving away from the previous ‘one size fits all’ radical approach. The goal is to spare morbidity whilst maintaining oncologic safety. In the upfront surgery setting, a first landmark [...] Read more.
Axillary surgery for patients with breast cancer (BC) in 2024 is becoming increasingly specific, moving away from the previous ‘one size fits all’ radical approach. The goal is to spare morbidity whilst maintaining oncologic safety. In the upfront surgery setting, a first landmark randomized controlled trial (RCT) on the omission of any surgical axillary staging in patients with unremarkable clinical examination and axillary ultrasound showed non-inferiority to sentinel lymph node (SLN) biopsy (SLNB). The study population consisted of 87.8% postmenopausal patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative BC. Patients with clinically node-negative breast cancer and up to two positive SLNs can safely be spared axillary dissection (ALND) even in the context of mastectomy or extranodal extension. In patients enrolled in the TAXIS trial, adjuvant systemic treatment was shown to be similar with or without ALND despite the loss of staging information. After neoadjuvant chemotherapy (NACT), targeted lymph node removal with or without SLNB showed a lower false-negative rate to determine nodal pathological complete response (pCR) compared to SLNB alone. However, oncologic outcomes do not appear to differ in patients with nodal pCR determined by either one of the two concepts, according to a recently published global, retrospective, real-world study. Real-world studies generally have a lower level of evidence than RCTs, but they are feasible quickly and with a large sample size. Another global real-world study provides evidence that even patients with residual isolated tumor cells can be safely spared from ALND. In general, few indications for ALND remain. Three randomized controlled trials are ongoing for patients with clinically node-positive BC in the upfront surgery setting and residual disease after NACT. Pending the results of these trials, ALND remains indicated in these patients. Full article
(This article belongs to the Special Issue Clinical Research and Progress in the Treatment of Breast Cancer)
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