Role of Proteases in Cancer
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3132
Special Issue Editors
Interests: gastrointestinal tumorigenesis; experimental mouse models of tumorigenesis; role of Kallikreins 6 in colorectal cancer and its utility as a biomarker and therapeutic target
Interests: heat shock proteins; envelope stress response; protein folding catalysts; prolyl isomerase; LPS biosynthesis; LPS assembly; LPS modifications; non-coding regulatory RNAs; proteases; phosphatases; kinases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Proteases are enzymes, which catalyze digestion of long proteins via hydrolysis of their peptide bonds into smaller polypeptides or single amino acids. Protein degradation, or proteolysis, is one of the most important processes in living organisms; therefore, proteases perform multiple functions in both normal and pathological states. Particularly, proteolytical degradation of extracellular matrix proteins by proteases is accepted as an event promoting neoplastic progression, although proteases that suppress cancer spreading have been identified as well.
Proteases perform complex and dynamic roles in cancer, as their expression is altered in most tumor cells. There are five major types of human protease classes established based on their catalytical mechanism: aspartic, cysteine, metalloproteinases, serine, and threonine. The roles of proteolytic enzymes may vary among cancer types and stages of malignant transformation and may include multiple classes of proteases and multiple proteolytic pathways within one type of cancer. Over the past four decades, significant information has been generated about the different functions of proteases in cancer. This Special issue will highlight the newest findings and advances in our understanding of proteinase-mediated molecular pathways in cancer.
Dr. Natalia A. Ignatenko
Dr. Gracjana Klein
Guest Editors
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Keywords
- signaling proteases
- proteolytic pathways
- protease imaging in cancer
- degradome
