Complexities in microRNA Function: Nuclear Roles, Sequence Variants and Non-canonical Gene Targeting
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 9548
Special Issue Editor
Interests: microRNAs; noncoding RNA; gene expression; cell signalling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
MicroRNAs have well established functions within the cytoplasm, acting as the recognition component of the RNA-induced silencing complex (RISC) to suppress gene expression through a combination of RNA target destabilisation and translational inhibition. However, there is a growing body of evidence suggesting additional complexities in microRNA function. For example, there are abundant mature microRNAs and RISC components within nuclei, though their roles and significance are less well understood. High-throughput sequencing-based studies have also revealed abundant naturally occurring microRNA sequence variants (isomiRs) and a diverse array of possible target binding “rules” through which microRNAs can interact with potential targets. This Special Edition highlights some of these “non-canonical” functions and complexities of microRNAs, beyond the traditional view of single microRNA sequences interacting with target mRNAs through well-defined “seed-based” interactions within the cytoplasm.
Dr. Cameron Bracken
Guest Editor
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Keywords
- microRNA
- isomiR
- RISC
- noncanonical microRNA targeting
- nuclear microRNAs