Cirrhosis: From Molecular Mechanisms to Therapies Strategies
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 430
Special Issue Editor
Interests: liver failure; organ support; hemodynamic monitoring; mechanical ventilation; shock
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic liver diseases and liver cirrhosis are major causes of morbidity and mortality worldwide. Chronic liver failure can have many different causes, and leads in time to severe liver fibrosis and progressive multiple organ dysfunction in the absence of liver transplantation. The prevalence of different chronic liver disease etiologies varies, however nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. In the recent years many advances were made in understanding the cellular and molecular mechanisms involved in the development of chronic liver disease and liver fibrosis. Recent findings reveal a close interaction between metabolic factors, inflammation, hemostasis and immunity contributing to the development of liver steatosis, hepatitis and fibrosis. The spectrum of chronic liver disease is large and, especially in advanced stages, engages different medical specialties. Even if the research already performed on this topic is comprehensive, there are still many unknowns, suggesting future opportunities for interdisciplinary research collaboration. Better defining the molecular mechanisms involved in the pathogenesis of liver steatosis and progression to fibrosis could lead to the development of novel treatment strategies, currently limited to liver transplantation for end-stage disease.
This Special Issue intends to present up-to-date reviews about the molecular aspects involved in the development of liver cirrhosis and new insights on the recent advances of therapies of advanced liver disease. We look forward to reading your contributions.
Dr. Dana Rodica Tomescu
Guest Editor
Manuscript Submission Information
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Keywords
- Liver cirrhosis
- Acute on Chronic Liver Failure
- Non-alcoholic fatty liver disease
- Molecular medicine
- Novel therapeutic strategies
