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Journals
Biomolecules
Special Issues
Bioactive Natural Products and Antioxidant Activity
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Bioactive Natural Products and Antioxidant Activity

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-inspired Molecules".

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 13601

Special Issue Editors

Dr. Alessandra Morana

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Guest Editor
Research Institute on Terrestrial Ecosystems (IRET), National Research Council of Italy (CNR), Via P. Castellino 111, 80131 Naples, Italy
Interests: bioactive compounds; waste valorization; antioxidants; pigments; extremophilic microorganisms
Special Issues, Collections and Topics in MDPI journals
Dr. Giuseppe Squillaci

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Guest Editor
Research Institute on Terrestrial Ecosystems (IRET), National Research Council of Italy (CNR), Via P. Castellino 111, 80131 Naples, Italy
Interests: sustainable extraction; polyphenols; antioxidant; waste valorization; exopolysaccharides; halophilic microorganisms circular economy; bioactive compounds
Special Issues, Collections and Topics in MDPI journals
Dr. Ismene Serino

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Guest Editor
Department of Experimental Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, via Costantinopoli, 16, 80138 Naples, Italy
Interests: melatonin; spermatogenesis; bioactive compounds; halophilic microorganisms; carotenoids

Special Issue Information

Dear Colleagues,

Molecules provided with antioxidant activity are of extraordinary interest, as they find application in many sectors from health to food, from cosmetics to pharmaceutics. Moreover, it is recognized that  antioxidant compounds are responsible for human health benefits through their ability to interact with the reactive oxygen and nitrogen species (ROS and RNS), highly reactive molecules that cause unwanted and harmful effects to cells, tissues, and organs.

The continuous growing demand of consumers for antioxidants of natural origin to use in substitution of the largely employed synthetic ones has enhanced the research of natural providers of bioactive molecules with antioxidant power.

The aim of the Special Issue, “Bioactive Natural Products and Antioxidant Activity”, is to collect the achievements in the field of natural antioxidants and their applications. The natural providers covered by this Special Issue belong to, but are not limited to, plant and microbial kingdoms, as they are capable of producing a wide variety of molecules endowed with antioxidant activity. These molecules range from phenolic compounds to pigments, from polysaccharides to enzymes and beyond.

We would like to invite researchers and scholars to participate in this Special Issue by submitting a contribution in their field of expertise. Both original research papers and reviews are welcome.

Dr. Alessandra Morana
Dr. Giuseppe Squillaci
Dr. Ismene Serino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • plant-based antioxidants
  • antioxidant enzymes
  • microbial antioxidant products
  • oxidative stress

Published Papers (4 papers)

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Research

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20 pages, 7482 KiB  
Article
(−)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer’s Disease PSEN1 E280A
by Viviana Soto-Mercado, Miguel Mendivil-Perez, Carlos Velez-Pardo and Marlene Jimenez-Del-Rio
Biomolecules 2021, 11(12), 1845; https://doi.org/10.3390/biom11121845 - 08 Dec 2021
Cited by 6 | Viewed by 2578
Abstract
Alzheimer’s disease (AD) is a complex neurodegenerative disease characterized by functional disruption, death of cholinergic neurons (ChNs) because of intracellular and extracellular Aβ aggregates, and hyperphosphorylation of protein TAU (p-TAU). To date, there are no efficient therapies against AD. Therefore, new therapies for [...] Read more.
Alzheimer’s disease (AD) is a complex neurodegenerative disease characterized by functional disruption, death of cholinergic neurons (ChNs) because of intracellular and extracellular Aβ aggregates, and hyperphosphorylation of protein TAU (p-TAU). To date, there are no efficient therapies against AD. Therefore, new therapies for its treatment are in need. The goal of this investigation was to evaluate the effect of the polyphenol epigallocatechin-3-gallate (EGCG) on cholinergic-like neurons (ChLNs) bearing the mutation E280A in PRESENILIN 1 (PSEN1 E280A). To this aim, wild-type (WT) and PSEN1 E280A ChLNs were exposed to EGCG (5–50 μM) for 4 days. Untreated or treated neurons were assessed for biochemical and functional analysis. We found that EGCG (50 μM) significantly inhibited the aggregation of (i)sAPPβf, blocked p-TAU, increased ∆Ψm, decreased oxidation of DJ-1 at residue Cys106-SH, and inhibited the activation of transcription factor c-JUN and P53, PUMA, and CASPASE-3 in mutant ChLNs compared to WT. Although EGCG did not reduce (e)Aβ42, the polyphenol reversed Ca2+ influx dysregulation as a response to acetylcholine (ACh) stimuli in PSEN1 E280A ChLNs, inhibited the activation of transcription factor NF-κB, and reduced the secretion of pro-inflammatory IL-6 in wild-type astrocyte-like cells (ALCs) when exposed to mutant ChLNs culture supernatant. Taken together, our findings suggest that the EGCG might be a promising therapeutic approach for the treatment of FAD. Full article
(This article belongs to the Special Issue Bioactive Natural Products and Antioxidant Activity)
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24 pages, 4897 KiB  
Article
Are Uropathogenic Bacteria Living in Multispecies Biofilm Susceptible to Active Plant Ingredient—Asiatic Acid?
by Zuzanna Sycz, Dorota Tichaczek-Goska, Anna Jezierska-Domaradzka and Dorota Wojnicz
Biomolecules 2021, 11(12), 1754; https://doi.org/10.3390/biom11121754 - 24 Nov 2021
Cited by 8 | Viewed by 1775
Abstract
Urinary tract infections (UTIs) are a serious health problem in the human population due to their chronic and recurrent nature. Bacteria causing UTIs form multispecies biofilms being resistant to the activity of the conventionally used antibiotics. Therefore, compounds of plant origin are currently [...] Read more.
Urinary tract infections (UTIs) are a serious health problem in the human population due to their chronic and recurrent nature. Bacteria causing UTIs form multispecies biofilms being resistant to the activity of the conventionally used antibiotics. Therefore, compounds of plant origin are currently being searched for, which could constitute an alternative strategy to antibiotic therapy. Our study aimed to determine the activity of asiatic acid (AA) against biofilms formed by uropathogenic Escherichia coli, Enterobacter cloacae, and Pseudomonas aeruginosa. The influence of AA on the survival, biofilm mass formation by bacteria living in mono-, dual-, and triple-species consortia as well as the metabolic activity and bacterial cell morphology were determined. The spectrophotometric methods were used for biofilm mass synthesis and metabolic activity determination. The survival of bacteria was established using the serial dilution assay. The decrease in survival and a weakening of the ability to create biofilms, both single and multi-species, as well as changes in the morphology of bacterial cells were noticed. As AA works best against young biofilms, the use of AA-containing formulations, especially during the initial stages of infection, seems to be reasonable. However, there is a need for further research concerning AA especially regarding its antibacterial mechanisms of action. Full article
(This article belongs to the Special Issue Bioactive Natural Products and Antioxidant Activity)
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13 pages, 4401 KiB  
Article
Rosinidin Attenuates Lipopolysaccharide-Induced Memory Impairment in Rats: Possible Mechanisms of Action Include Antioxidant and Anti-Inflammatory Effects
by Sultan Alshehri and Syed Sarim Imam
Biomolecules 2021, 11(12), 1747; https://doi.org/10.3390/biom11121747 - 23 Nov 2021
Cited by 11 | Viewed by 1790
Abstract
The investigation aimed to evaluate the favourable effects of rosinidin in lipopolysaccharide (LPS)-induced learning and memory impairment in rats. Adult Wistar rats (150–200 g) were segregated equally into four different groups and treated as below: Group 1 (normal) and Group 2 (LPS control) [...] Read more.
The investigation aimed to evaluate the favourable effects of rosinidin in lipopolysaccharide (LPS)-induced learning and memory impairment in rats. Adult Wistar rats (150–200 g) were segregated equally into four different groups and treated as below: Group 1 (normal) and Group 2 (LPS control) were administered orally with 3 mL of 0.5% SCMC (vehicle); Group 3 and Group 4 were test groups and orally administered with rosinidin lower dose (10 mg/kg) and higher dose 20 mg/kg. Daily, 1 h post-offer mentioned treatments, Group 1 animals were injected with normal saline (i.p.) and groups 2–4 were treated with 1 mg/kg/day of LPS. This treatment schedule was followed daily for 7 days. During the treatment, schedule rats were evaluated for spontaneous locomotor activity, memory, and learning abilities. The biochemical assessment was carried out of acetylcholine esterase (AChE), endogenous antioxidants (GSH, SOD, GPx, and catalase), oxidative stress marker MDA, neuroinflammatory markers (IL-6, IL-1β, TNF-α, and NF-κB), and BDNF. LPS-induced reduced spontaneous locomotor activity and memory impairment in the animals. Moreover, LPS reduced GSH, SOD, GPx, and catalase levels; altered activities of AChE; elevated levels of MDA, IL-6, IL-1β, TNF-α, and NF-κB; and attenuated the levels of BDNF in brain tissue. Administration of rosinidin to LPS-treated animals significantly reduced LPS-induced neurobehavioral impairments, oxidative stress, neuroinflammatory markers, and reversed the Ach enzyme activities and BDNF levels towards normal. Results demonstrated that rosinidin attenuates the effects of LPS on learning memory in rats. Full article
(This article belongs to the Special Issue Bioactive Natural Products and Antioxidant Activity)
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Review

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26 pages, 1148 KiB  
Review
Health Benefits and Pharmacological Properties of Carvone
by Abdelhakim Bouyahya, Hamza Mechchate, Taoufiq Benali, Rokia Ghchime, Saoulajan Charfi, Abdelaali Balahbib, Pavel Burkov, Mohammad Ali Shariati, Jose M. Lorenzo and Nasreddine El Omari
Biomolecules 2021, 11(12), 1803; https://doi.org/10.3390/biom11121803 - 01 Dec 2021
Cited by 51 | Viewed by 6292
Abstract
Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. [...] Read more.
Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested. Full article
(This article belongs to the Special Issue Bioactive Natural Products and Antioxidant Activity)
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