Key Molecules in Traditional Medicine: From Molecular Mechanisms to Therapies Strategies

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-inspired Molecules".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 913

Special Issue Editors


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Guest Editor
Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
Interests: Parkinson's disease; pain; acupuncture; medicinal herbs; neuroprotection; inflammation
Special Issues, Collections and Topics in MDPI journals
KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
Interests: neuropsychiatric disorders; neuropsychopharmacology; acupuncture; medicinal herbs; neuroprotection; inflammation

Special Issue Information

Dear Colleagues,

Traditional medicine has a long history and has been used to maintain health as well as prevent, diagnose, ameliorate, or treat physical and mental illnesses. It is still widely practiced throughout the world, and the efficacy as well as mechanisms of various traditional treatments, such as acupuncture, moxibustion, and Ayurveda, have been supported by many scientific studies. As a result, a chapter on traditional medicine has been included in the International Statistical Classification of Diseases and Related Health Problems (ICD-11).

This Special Issue aims to identify the molecular mechanisms of traditional medicine and covers topics ranging from demonstrating the efficacy of natural compounds to exploring biomolecules associated with the efficacy of traditional medicine treatments. This Special Issue will include all studies on biomolecules related to the effects of the mechanisms of traditional medicine using a variety of methodologies, including in silico, in vitro, and in vivo studies. We invite original research articles and reviews that highlight significant advances in these areas.

Prof. Dr. Seungtae Kim
Dr. Sunoh Kwon
Guest Editors

Manuscript Submission Information

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Keywords

  • natural compounds
  • traditional medicine
  • biomolecules in medicinal herbs
  • molecular changes caused by traditional medicine treatments

Published Papers (1 paper)

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Review

54 pages, 3726 KiB  
Review
Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects
by Ting Cui, Bo-Yu Li, Fei Liu and Liang Xiong
Biomolecules 2024, 14(4), 387; https://doi.org/10.3390/biom14040387 - 23 Mar 2024
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Abstract
Curcumae Rhizoma, a traditional Chinese medicine with a wide range of pharmacological activities, is obtained from the dried rhizomes of Curcuma phaeocaulis VaL., Curcuma kwangsiensis S. G. Lee et C. F. Liang, and Curcuma wenyujin Y. H. Chen et C. Ling. Sesquiterpenoids [...] Read more.
Curcumae Rhizoma, a traditional Chinese medicine with a wide range of pharmacological activities, is obtained from the dried rhizomes of Curcuma phaeocaulis VaL., Curcuma kwangsiensis S. G. Lee et C. F. Liang, and Curcuma wenyujin Y. H. Chen et C. Ling. Sesquiterpenoids and curcuminoids are found to be the main constituents of Curcumae Rhizoma. Sesquiterpenoids are composed of three isoprene units and are susceptible to complex transformations, such as cyclization, rearrangement, and oxidation. They are the most structurally diverse class of plant-based natural products with a wide range of biological activities and are widely found in nature. In recent years, scholars have conducted abundant studies on the structures and pharmacological properties of components of Curcumae Rhizoma. This article elucidates the chemical structures, medicinal properties, and biological properties of the sesquiterpenoids (a total of 274 compounds) isolated from Curcumae Rhizoma. We summarized extraction and isolation methods for sesquiterpenoids, established a chemical component library of sesquiterpenoids in Curcumae Rhizoma, and analyzed structural variances among sesquiterpenoids sourced from Curcumae Rhizoma of diverse botanical origins. Furthermore, our investigation reveals a diverse array of sesquiterpenoid types, encompassing guaiane-type, germacrane-type, eudesmane-type, elemane-type, cadinane-type, carane-type, bisabolane-type, humulane-type, and other types, emphasizing the relationship between structural diversity and activity. We hope to provide a valuable reference for further research and exploitation and pave the way for the development of new drugs derived from medicinal plants. Full article
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