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Biomolecules
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State-of-the-Art Cell Death in France 2020-2021
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State-of-the-Art Cell Death in France 2020-2021

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 13244

Special Issue Editor

Dr. Stéphen T. Manon

E-Mail Website
Guest Editor
Institut de Biochimie et de Génétique Cellulaires, Université de Bordeaux, CNRS, UMR 5095, 1 Rue Camille Saint-Saëns, 33077 Bordeaux, France
Interests: apoptosis; Bcl-2 family; mitochondria; membrane proteins; structure/function studies; ectopic expression; liposomes; nanodiscs

Special Issue Information

Dear Colleagues,

This Special Issue aims to provide a comprehensive overview of State-of-the-Art Cell Death in France 2020-2021. We invite research papers that will consolidate our understanding in this area. The Special Issue will publish full research articles and systematic reviews. Potential topics include, but are not limited to, the following research areas:

  • Cell death in mammals: molecular aspects, regulation, modulation, and targeting
  • Non-apoptotic cell death, immunity, and viruses
  • Cell death, metabolic disorders and ageing
  • Cell death in microorganisms and non-conventional models

Dr. Stéphen T. Manon 
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cell death in mammals
  • Non-apoptotic cell death, immunity, and viruses
  • Cell death, metabolic disorders and ageing
  • Cell death in microorganisms and non-conventional models

Published Papers (4 papers)

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Research

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18 pages, 3626 KiB  
Article
Apoptosis Quantification in Tissue: Development of a Semi-Automatic Protocol and Assessment of Critical Steps of Image Processing
by Juliette de Noiron, Marion Hoareau, Jessie Colin and Isabelle Guénal
Biomolecules 2021, 11(10), 1523; https://doi.org/10.3390/biom11101523 - 15 Oct 2021
Cited by 4 | Viewed by 2866
Abstract
Apoptosis is associated with numerous phenotypical characteristics, and is thus studied with many tools. In this study, we compared two broadly used apoptotic assays: TUNEL and staining with an antibody targeting the activated form of an effector caspase. To compare them, we developed [...] Read more.
Apoptosis is associated with numerous phenotypical characteristics, and is thus studied with many tools. In this study, we compared two broadly used apoptotic assays: TUNEL and staining with an antibody targeting the activated form of an effector caspase. To compare them, we developed a protocol based on commonly used tools such as image filtering, z-projection, and thresholding. Even though it is commonly used in image-processing protocols, thresholding remains a recurring problem. Here, we analyzed the impact of processing parameters and readout choice on the accuracy of apoptotic signal quantification. Our results show that TUNEL is quite robust, even if image processing parameters may not always allow to detect subtle differences of the apoptotic rate. On the contrary, images from anti-cleaved caspase staining are more sensitive to handle and necessitate being processed more carefully. We then developed an open-source Fiji macro automatizing most steps of the image processing and quantification protocol. It is noteworthy that the field of application of this macro is wider than apoptosis and it can be used to treat and quantify other kind of images. Full article
(This article belongs to the Special Issue State-of-the-Art Cell Death in France 2020-2021)
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Review

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29 pages, 1408 KiB  
Review
Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network
by Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jérôme Estaquier, Germain Gillet, Isabelle Guénal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stéphen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernard Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Luc Poyet, Muriel Priault, Jean-Ehrland Ricci, Franck B. Riquet, Santos A. Susin, Magali Suzanne, Pierre Vacher, Ludivine Walter and Bertrand Mollereauadd Show full author list remove Hide full author list
Biomolecules 2022, 12(7), 901; https://doi.org/10.3390/biom12070901 - 28 Jun 2022
Cited by 2 | Viewed by 3327
Abstract
Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although many aspects of regulated [...] Read more.
Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although many aspects of regulated cell death still remain to be elucidated in specific cell subtypes and disease conditions, many predicted that research into cell death was inexorably reaching a plateau. However, this was not the case since the last decade saw a multitude of cell death modalities being described, while harnessing their therapeutic potential reached clinical use in certain cases. In line with keeping research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN). The research conducted by FCDRN is at the leading edge of emerging topics such as non-apoptotic functions of apoptotic effectors, paracrine effects of cell death, novel canonical and non-canonical mechanisms to induce apoptosis in cell death-resistant cancer cells or regulated forms of necrosis and the associated immunogenic response. Collectively, these various lines of research all emerged from the study of apoptosis and in the next few years will increase the mechanistic knowledge into regulated cell death and how to harness it for therapy. Full article
(This article belongs to the Special Issue State-of-the-Art Cell Death in France 2020-2021)
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19 pages, 7615 KiB  
Review
Cytoplasmic and Nuclear Functions of cIAP1
by Aymeric Zadoroznyj and Laurence Dubrez
Biomolecules 2022, 12(2), 322; https://doi.org/10.3390/biom12020322 - 17 Feb 2022
Cited by 9 | Viewed by 3078
Abstract
Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by [...] Read more.
Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some cytokine receptors and pattern recognition-receptors (PRRs). Although less documented, cIAP1 has also been involved in the regulation of cell migration and in the control of transcriptional programs. Full article
(This article belongs to the Special Issue State-of-the-Art Cell Death in France 2020-2021)
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19 pages, 2721 KiB  
Review
Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death
by Lisenn Lalier, François Vallette and Stéphen Manon
Biomolecules 2022, 12(2), 162; https://doi.org/10.3390/biom12020162 - 19 Jan 2022
Cited by 28 | Viewed by 3330
Abstract
The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a crucial step in the implementation of apoptosis. We review evidence showing the role of the components of the mitochondrial import machineries (translocase of the outer membrane (TOM) and the [...] Read more.
The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a crucial step in the implementation of apoptosis. We review evidence showing the role of the components of the mitochondrial import machineries (translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM)) in the mitochondrial localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting cells and in cells committed into apoptosis. Full article
(This article belongs to the Special Issue State-of-the-Art Cell Death in France 2020-2021)
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