Lipopolysaccharides: the Structure, Structure-Function Relationship, Signalling, Biological Effects and Removal
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Carbohydrates".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 2911
Special Issue Editor
Interests: lipopolysacharide; cyanoatoxins; intestinal epithelium; inflammation; innate immunity; Toll-like receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipopolysaccharides (LPS) are a part of the cell membranes of Gram-negative bacteria and cyanobacteria. LPS of some species are known to induce inflammation, pyrogenic reactions, or even septic shock via toll-like receptor 4. On the other hand, antagonistic LPS and also non-receptor-mediated activation were described. LPS can contaminate commercially produced proteins and bioactive compounds but they are also a part of, e.g., cyanobacterial water blooms. Therefore, methods of their removal and to control their levels are needed. Furthermore, the structure of LPS differs among species but it is not known in many cases and structure–function relationships are not described well.
This Special Issue will highlight various types of bioactivity of LPS from Gram-negative bacteria and cyanobacteria according to their structures, (non-)pyrogenic properties, and/or mechanisms of signaling. Research articles and reviews focused on structure description, structure–function relationship studies, bioactivity assays, analyses of mechanisms of action, new methods of removal and risk analyses of LPS are welcome. Articles using state-of-the-art in vitro and in vivo models in biological studies are highly appreciated.
Dr. Lenka Šindlerová
Guest Editor
Manuscript Submission Information
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Keywords
- Lipopolysaccharide
- Bioactivity
- Structure
- Mechanism of action
- Removal
- Structure-function relationship
- Gram-negative bacteria
- Cyanobacteria
- Pyrogenicity
- Inflammation
- Risk assessment
