Infective Hypothesis for Neurodegenerative Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 6645
Special Issue Editor
Interests: neurodegenerative diseases; aging; inflammation; diagnostic biomarker discovery; immune alterations; metabolic alterations; transgenic mouse models; saliva
Special Issue Information
Dear colleagues
Recent works speculate that a combination of genetic and environmental factors may result in neurodegenerative diseases like Alzheimer’s, Parkinson’s, and multiple sclerosis. It is known that disease-causing mutations in several genes for Parkinson’s disease or Huntington’s disease are related to increased susceptibility to intracellular microbial infections. Recent data have demonstrated these genes may modulate innate immune responses, suggesting that immune dysregulation may play an important role in neurodegeneration. A number of observations suggest that microbial colonization, including bacterial, fungal, and viral infections, may be a risk factor for neurodegenerative diseases and might explain why the onset of these disorders appears after several decades of life.
It is my great pleasure to invite you and your teams, as experts from diverse backgrounds (medicine, immunology, clinics, genetics, molecular biology, and epidemiology), to contribute original research or review articles. We are especially interested in articles that cover studies on the identification, roles, and molecular mechanisms of microbial infection and translational approaches of clinical relevance in neurodegenerative diseases.
Prof. Eva M. Carro
Guest Editor
Manuscript Submission Information
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Keywords
- Alzheimer’s disease
- Parkinson´s disease
- Huntington´s disease
- neurodegeneration
- infectious pathogens
- antimicrobial peptides
- neuroinflammation
- oral infection
