Molecular Mechanisms Underlying Liver Diseases

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1274

Special Issue Editor

Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Interests: alcohol-associated liver disease; gut microbiota; lipid metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The liver, a central metabolic hub in the human body, plays a pivotal role in maintaining homeostasis and overall health. As an organ of paramount importance, the liver is susceptible to a myriad of diseases, necessitating a comprehensive exploration of the underlying molecular mechanisms. This Special Issue aims to decipher the underlying molecular landscapes governing liver diseases, shedding light on novel insights and potential therapeutic avenues.

This collection of articles aims at addressing a diverse spectrum of liver disorders, encompassing metabolic conditions such as alcohol-associated liver disease and metabolic-associated fatty liver disease, along with viral infections and hepatocellular carcinoma. Our goal is to provide a multifaceted examination of these liver-related pathologies, offering valuable insights into their molecular mechanisms. Furthermore, we recognize the liver not in isolation but as a dynamic organ that engages in constant crosstalk with other physiological systems. Investigating the dynamic interactions between the liver and other organs is integral to our endeavor, as these interactions play a pivotal role in shaping the overall impact of liver diseases on the body. This Special Issue seeks to foster a nuanced understanding of the interplay between molecular factors, genetic determinants, and organ–organ interactions, aiming to contribute meaningfully to the field of hepatic pathophysiology.

In summary, this collection serves as a comprehensive exploration of liver diseases, aiming to unravel the complex tapestry of molecular mechanisms underlying their etiology, progression, and potential therapeutic interventions.

Dr. Wei Zhong
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathogenesis of liver diseases
  • molecular mechanisms
  • organelle damages
  • genetic determinants
  • organ–organ interactions
  • biomarkers
  • in vivo models of liver diseases
  • therapeutic insights

Published Papers (1 paper)

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Research

14 pages, 4241 KiB  
Article
Peripheral Lymphocytes in Primary Liver Cancers: Elevated NK and CD8+ T Cells and Dysregulated Selenium Metabolism
by Cheng Zhou, Zhufeng Lu, Baoye Sun, Yong Yi, Boheng Zhang, Zheng Wang and Shuang-Jian Qiu
Biomolecules 2024, 14(2), 222; https://doi.org/10.3390/biom14020222 - 14 Feb 2024
Viewed by 1126
Abstract
Peripheral blood lymphocytes (PBLs), which play a pivotal role in orchestrating the immune system, garner minimal attention in hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The impact of primary liver cancers on PBLs remains unexplored. In this study, flow cytometry facilitated the quantification [...] Read more.
Peripheral blood lymphocytes (PBLs), which play a pivotal role in orchestrating the immune system, garner minimal attention in hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The impact of primary liver cancers on PBLs remains unexplored. In this study, flow cytometry facilitated the quantification of cell populations, while transcriptome of PBLs was executed utilizing 10× single-cell sequencing technology. Additionally, pertinent cases were curated from the GEO database. Subsequent bioinformatics and statistical analyses were conducted utilizing R (4.2.1) software. Elevated counts of NK cells and CD8+ T cells were observed in both ICC and HCC when compared to benign liver disease (BLD). In the multivariate Cox model, NK cells and CD8+ T cells emerged as independent risk factors for recurrence-free survival. Single-cell sequencing of PBLs uncovered the downregulation of TGFβ signaling in tumor-derived CD8+ T cells. Pathway enrichment analysis, based on differential expression profiling, highlighted aberrations in selenium metabolism. Proteomic analysis of preoperative and postoperative peripheral blood samples from patients undergoing tumor resection revealed a significant upregulation of SELENBP1 and a significant downregulation of SEPP1. Primary liver cancer has a definite impact on PBLs, manifested by alterations in cellular quantities and selenoprotein metabolism. Full article
(This article belongs to the Special Issue Molecular Mechanisms Underlying Liver Diseases)
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