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8.3
5.5
Journals
Biomolecules
Special Issues
Vascular Disease and Thrombosis
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Vascular Disease and Thrombosis

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1716

Special Issue Editor

Dr. Raffaele Serra

E-Mail Website
Guest Editor
Vascular Surgery Unit, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Dulbecco University Hospital, 88100 Catanzaro, Italy
Interests: wound healing; vascular surgery; metabolic syndrome; treatment; vascular medicine; reconstructive surgery; general surgery; diabetes; atherosclerosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are seeking submissions for a Special Issue of Biomolecules on vascular disease and thrombosis.

Vascular disease and thrombosis cause morbidity and mortality worldwide. In this area, on the venous side, the most common clinical manifestation is a venous thromboembolism (VTE) (this includes superficial and deep vein thrombosis, pulmonary embolism, and post-thrombotic syndrome). On the arterial side, the most common clinical manifestations are ischemic heart disease (including acute myocardial infarction), ischemic stroke, acute limb ischemia, intestinal infarction, etc. Research focused on biomolecular events is crucial to the prevention and treatment of thrombovascular diseases.

For this Special Issue, both research and review articles (general and systematic) are welcome.

Dr. Raffaele Serra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • venous thromboembolism
  • superficial vein thrombosis
  • deep vein thrombosis
  • pulmonary embolism
  • post-thrombotic syndrome
  • ischemic heart disease
  • acute myocardial infarction
  • ischemic stroke
  • acute limb ischemia
  • intestinal infarction
  • biomarkers
  • hematologic disorders
  • thrombophilias

Published Papers (1 paper)

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Research

15 pages, 4090 KiB  
Article
Identification of Genes and miRNAs Associated with TAFI-Related Thrombosis: An in Silico Study
by Erasmia Rouka, Sotirios G. Zarogiannis, Chrissi Hatzoglou, Konstantinos I. Gourgoulianis and Foteini Malli
Biomolecules 2023, 13(9), 1318; https://doi.org/10.3390/biom13091318 - 28 Aug 2023
Viewed by 1449
Abstract
Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) is a carboxypeptidase B-like proenzyme encoded by the CPB2 gene. After thrombin activation, TAFI downregulates fibrinolysis, thus linking the latter with coagulation. TAFI has been shown to play a role in venous and arterial thrombotic diseases, yet, data regarding [...] Read more.
Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) is a carboxypeptidase B-like proenzyme encoded by the CPB2 gene. After thrombin activation, TAFI downregulates fibrinolysis, thus linking the latter with coagulation. TAFI has been shown to play a role in venous and arterial thrombotic diseases, yet, data regarding the molecular mechanisms underlying its function have been conflicting. In this study, we focused on the prediction and functional enrichment analysis (FEA) of the TAFI interaction network and the microRNAs (miRNAs) targeting the members of this network in an attempt to identify novel components and pathways of TAFI-related thrombosis. To this end, we used nine bioinformatics software tools. We found that the TAFI interactome consists of 28 unique genes mainly involved in hemostasis. Twenty-four miRNAs were predicted to target these genes. Co-annotation analysis of the predicted interactors with respect to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and transcription factors (TFs) pointed to the complement and coagulation cascades as well as neutrophil extracellular trap formation. Cancer, stroke, and intracranial aneurysm were among the top 20 significant diseases related to the identified miRNAs. We reason that the predicted biomolecules should be further studied in the context of TAFI-related thrombosis. Full article
(This article belongs to the Special Issue Vascular Disease and Thrombosis)
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