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Biomolecules
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Bionanocomposites
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Bionanocomposites

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological and Bio- Materials".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 21232

Special Issue Editor

Dr. Carole Aimé

E-Mail Website
Guest Editor
CNRS, Department of Chemistry, Ecole Normale Supérieure de Paris, Paris, France
Interests: self-assembly; extra cellular matrix; collagen; tissue engineering; bio-microfluidics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bionanocomposites can be defined as a group of materials consisting of a biological component associated with another counterpart, which can be of diverse chemical nature, being either organic, including biomolecules, or inorganic. What defines bionanocomposites as a group is the idea of using biomolecules to integrate, i.e., make use of, their molecular recognition properties to direct assembly of functional structures and/or drive interactions with living systems. This is particularly relevant for solving problems in a biomedical context and is based on an interdisciplinary approach based on chemistry and supramolecular self-assembly, nanotechnology, and regenerative medicine. This Special Issue aims to illustrate the diversity of approaches, particularly in the choice of biomolecules and the nature of the associated counterpart—biomolecules, polymers, inorganic nanoparticles—defining bionanocomposites with their great modularity and offering an almost infinite number of accessible functions.

Dr. Carole Aimé
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • DNA origami
  • Protein
  • Hybrid polymer-based biomaterials
  • Nanoparticles
  • Bioactive nanomaterials
  • Assembly of functional nanostructures
  • Regenerative medicine

Published Papers (5 papers)

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Research

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9 pages, 1464 KiB  
Communication
DNA-Directed Assembly of Carbon Nanotube–Protein Hybrids
by Mark Freeley, Rebecca E. A. Gwyther, D. Dafydd Jones and Matteo Palma
Biomolecules 2021, 11(7), 955; https://doi.org/10.3390/biom11070955 - 29 Jun 2021
Cited by 8 | Viewed by 3074
Abstract
Here, we report the controlled assembly of SWCNT–GFP hybrids employing DNA as a linker. Two distinct, enriched SWCNTs chiralities, (6,5), (7,6), and an unsorted SWCNT solution, were selectively functionalized with DNA and hybridized to a complementary GFPDNA conjugate. Atomic force microscopy images [...] Read more.
Here, we report the controlled assembly of SWCNT–GFP hybrids employing DNA as a linker. Two distinct, enriched SWCNTs chiralities, (6,5), (7,6), and an unsorted SWCNT solution, were selectively functionalized with DNA and hybridized to a complementary GFPDNA conjugate. Atomic force microscopy images confirmed that GFP attachment occurred predominantly at the terminal ends of the nanotubes, as designed. The electronic coupling of the proteins to the nanotubes was confirmed via in-solution fluorescence spectroscopy, that revealed an increase in the emission intensity of GFP when linked to the CNTs. Full article
(This article belongs to the Special Issue Bionanocomposites)
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16 pages, 9809 KiB  
Article
Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials
by Nicolas Debons, Kenta Matsumoto, Noriyuki Hirota, Thibaud Coradin, Toshiyuki Ikoma and Carole Aimé
Biomolecules 2021, 11(5), 749; https://doi.org/10.3390/biom11050749 - 18 May 2021
Cited by 6 | Viewed by 2621
Abstract
Major progress in the field of regenerative medicine is expected from the design of artificial scaffolds that mimic both the structural and functional properties of the ECM. The bionanocomposites approach is particularly well fitted to meet this challenge as it can combine ECM-based [...] Read more.
Major progress in the field of regenerative medicine is expected from the design of artificial scaffolds that mimic both the structural and functional properties of the ECM. The bionanocomposites approach is particularly well fitted to meet this challenge as it can combine ECM-based matrices and colloidal carriers of biological cues that regulate cell behavior. Here we have prepared bionanocomposites under high magnetic field from tilapia fish scale collagen and multifunctional silica nanoparticles (SiNPs). We show that scaffolding cues (collagen), multiple display of signaling peptides (SiNPs) and control over the global structuration (magnetic field) can be combined into a unique bionanocomposite for the engineering of biomaterials with improved cell performances. Full article
(This article belongs to the Special Issue Bionanocomposites)
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20 pages, 9518 KiB  
Article
Ameliorated Antibacterial and Antioxidant Properties by Trichoderma harzianum Mediated Green Synthesis of Silver Nanoparticles
by Narasimhamurthy Konappa, Arakere C. Udayashankar, Nirmaladevi Dhamodaran, Soumya Krishnamurthy, Shubha Jagannath, Fazilath Uzma, Chamanahalli Kyathegowda Pradeep, Savitha De Britto, Srinivas Chowdappa and Sudisha Jogaiah
Biomolecules 2021, 11(4), 535; https://doi.org/10.3390/biom11040535 - 04 Apr 2021
Cited by 53 | Viewed by 4252
Abstract
Biosynthesis of silver nanoparticles using beneficial Trichoderma harzianum is a simple, eco-friendly and cost-effective route. Secondary metabolites secreted by T. harzianum act as capping and reducing agents that can offer constancy and can contribute to biological activity. The present study aimed to synthesize [...] Read more.
Biosynthesis of silver nanoparticles using beneficial Trichoderma harzianum is a simple, eco-friendly and cost-effective route. Secondary metabolites secreted by T. harzianum act as capping and reducing agents that can offer constancy and can contribute to biological activity. The present study aimed to synthesize silver nanoparticles using T. harzianum cell filtrate and investigate different bioactive metabolites based on LC-MS/MS analysis. The synthesized silver nanoparticles (AgNPs) from T. harzianum were characterized by ultraviolet–visible spectrophotometry, Fourier transform infrared spectrometry (FT-IR), energy-dispersive spectroscopy (EDS), dynamic light scattering (DLS), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The surface plasmon resonance of synthesized particles formed a peak centered near 438 nm. The DLS study determined the average size of AgNPs to be 21.49 nm. The average size of AgNPs was measured to be 72 nm by SEM. The cubic crystal structure from XRD analysis confirmed the synthesized particles as silver nanoparticles. The AgNPs exhibited remarkable antioxidant properties, as determined by DPPH and ferric reducing antioxidant power (FRAP) assay. The AgNPs also exhibited broad-spectrum antibacterial activity against two Gram-positive bacteria (S. aureus and B. subtilis) and two Gram-negative bacteria (E. coli and R. solanacearum). The minimum inhibitory concentration (MIC) of AgNPs towards bacterial growth was evaluated. The antibacterial activity of AgNPs was further confirmed by fluorescence microscopy and SEM analysis. Full article
(This article belongs to the Special Issue Bionanocomposites)
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24 pages, 4918 KiB  
Article
Nettle-Leaf Extract Derived ZnO/CuO Nanoparticle-Biopolymer-Based Antioxidant and Antimicrobial Nanocomposite Packaging Films and Their Impact on Extending the Post-Harvest Shelf Life of Guava Fruit
by Anu Kalia, Manpreet Kaur, Ashwag Shami, Sukhjit Kaur Jawandha, Mousa A. Alghuthaymi, Anirudh Thakur and Kamel A. Abd-Elsalam
Biomolecules 2021, 11(2), 224; https://doi.org/10.3390/biom11020224 - 05 Feb 2021
Cited by 40 | Viewed by 5044
Abstract
Green synthesized metal oxide nanoparticles (NPs) have prominent applications in antimicrobial packaging systems. Here we have attempted for the fabrication of chitosan-based nanocomposite film containing Urtica dioica leaf extract derived copper oxide (CuO) and zinc oxide (ZnO) NPs for shelf-life extension of the [...] Read more.
Green synthesized metal oxide nanoparticles (NPs) have prominent applications in antimicrobial packaging systems. Here we have attempted for the fabrication of chitosan-based nanocomposite film containing Urtica dioica leaf extract derived copper oxide (CuO) and zinc oxide (ZnO) NPs for shelf-life extension of the packaged guava fruits. Electron microscopy and spectroscopy analysis of the CuO and ZnO NPs exhibited nano-scale size, spherical morphologies, and negative ζ-potential values. The NPs possessed appreciable antioxidant and antimicrobial activity (AMA) in order of CuO NPs > ZnO NPs > nettle extract. Therefore, this work establishes for the first time the successful synthesis of CuO NPs and compares its antimicrobial and antioxidant properties with ZnO NPs. On incorporation in chitosan, the polymer nanocomposite films were developed by solvent casting technique. The developed films were transparent, had low antioxidant but substantial AMA. The NP supplementation improved the film characteristics as evident from the decrease in moisture content, water holding capacity, and solubility of the films. The nanocomposite films improved the quality attributes and shelf life of guava fruits by one week on packaging and storage compared to unpackaged control fruits. Therefore, this study demonstrates the higher antimicrobial potential of the nettle leaf extract derived CuO/ZnO NPs for development of antimicrobial nanocomposite films as a promising packaging solution for enhancing the shelf life of various perishable fruits. Full article
(This article belongs to the Special Issue Bionanocomposites)
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Review

Jump to: Research

39 pages, 3010 KiB  
Review
Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders
by Khadijeh Koushki, Sanaz Keshavarz Shahbaz, Mohsen Keshavarz, Evgeny E. Bezsonov, Thozhukat Sathyapalan and Amirhossein Sahebkar
Biomolecules 2021, 11(9), 1289; https://doi.org/10.3390/biom11091289 - 30 Aug 2021
Cited by 27 | Viewed by 5053
Abstract
Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-loading capacity and relative availability for modification accompanied by [...] Read more.
Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-loading capacity and relative availability for modification accompanied by non-cytotoxicity and biocompatibility, make them an ideal field of research in bio-nanotechnology. Moreover, their potential to alleviate various inflammatory factors, nitrite species, and reactive oxygen production and the capacity to deliver therapeutic agents has attracted attention for further studies in inflammatory and autoimmune disorders. Furthermore, the characteristics of GNPs and surface modification can modulate their toxicity, biodistribution, biocompatibility, and effects. This review discusses in vitro and in vivo effects of GNPs and their functionalized forms in managing various autoimmune disorders (Ads) such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis. Full article
(This article belongs to the Special Issue Bionanocomposites)
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