Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 1004
Special Issue Editors
Interests: ferroptosis; lipid metabolism; cancer metabolism; cardiovascular diseases; drug development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This year marks the 25th anniversary of the publication of Professor Ho Jeong Kwon’s paper (PNAS, 95:3356, 1998), in which he reported a new inventory of biological tools using “depudecin’ as a pharmacologically active compound for the study of, and for medical intervention in, basic biological processes. This paper stimulated the interest of many researchers and physicians to explore the biological role of histone deacetylases in gene regulation.
The addition of depudecin to pharmacopoeia has the potential to contribute to both basic and clinical science; for instance, its novel structure has already contributed to the understanding of the enzymatic mechanisms of action of the deacetylases, and it may further have unique advantages for therapeutic purposes. The past 25 years have witnessed intense scientific efforts to discover new biomolecules for advancing biology and biomedical applications. Professor Kwon has been at the forefront of these innovative efforts, conducting pioneering research on some of the angiogenesis- and autophagy-regulating biomolecules such as terpestacin, curcumin, kaempferide, Rg3, sertraline, artemisinate, daptomycin, voacangine, crytotashinone, etc., as well as on the biological roles of the targets of these biomolecules and their translational applications in health and disease, providing insights into the “biomolecule-target-phenotype’ link in biology and translational applications.
This Special Issue aims to focus on the role of biomolecules and their impact on biology and translational applications. It will begin with a brief review of Professor Kwon’s contributions to this field, followed by original research articles and reviews on all aspects of the molecular mechanisms and functional actions of biomolecules and their applications in health and disease.
Dr. Eun-Woo Lee
Dr. Hye Jin Kang
Guest Editors
Manuscript Submission Information
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Keywords
- biomolecules
- cancer
- angiogenesis
- autophagy
- GPCRs
- translational applications
- target identification
- proximity-labeling
- molecular docking
- molecular probe
- molecular pharmacology
