Viral Respiratory Infection including COVID-19: From Molecular Mechanisms to Therapies Strategies

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 856

Special Issue Editors


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Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy
Interests: clinical pharmacology; infectious diseases; antimicrobial agents
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Guest Editor
Toxicology Department of Oncology and Hemato-Oncology, University of Milan, Via Vanvitelli, 20133 Milan, Italy
Interests: cancer; antibiotic; treatement
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The background of this issue stems from the global pandemic caused by the SARS-CoV-2 virus, which has led to an urgent need for effective therapies to treat not only COVID-19 but other viral respiratory infections as well.  These infections continue to pose significant threats to global health and economies, highlighting the importance of this special issue.  The primary goal of this special issue is to provide a comprehensive platform for researchers worldwide to share their latest findings, insights, and advancements in identifying and validating therapeutic targets for viral respiratory infections.  This includes the development and evaluation of novel drugs, antibodies, and vaccines.  Ultimately, the insights gained from this special issue will contribute to the global efforts in combating viral respiratory infections and reducing their impact on society.

Prof. Dr. Francesco Scaglione
Dr. Arianna Pani
Guest Editors

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Keywords

  • post-COVID
  • syndrome
  • COVID-19
  • viral respiratory infections
  • SARS-CoV-2

Published Papers (1 paper)

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Research

14 pages, 2275 KiB  
Article
COVID-Vaccines in Pregnancy: Maternal and Neonatal Response over the First 9 Months after Delivery
by Alice Proto, Stefano Agliardi, Arianna Pani, Silvia Renica, Gianluca Gazzaniga, Riccardo Giossi, Michele Senatore, Federica Di Ruscio, Daniela Campisi, Chiara Vismara, Valentina Panetta, Francesco Scaglione and Stefano Martinelli
Biomolecules 2024, 14(4), 435; https://doi.org/10.3390/biom14040435 - 03 Apr 2024
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Abstract
Vaccination against SARS-CoV-2 has been demonstrated to be safe during gestation. Nevertheless, there are no robust data investigating the entity of maternal antibodies’ transmission through the placenta to the newborn and the persistence of the antibodies in babies’ serum. The objective of this [...] Read more.
Vaccination against SARS-CoV-2 has been demonstrated to be safe during gestation. Nevertheless, there are no robust data investigating the entity of maternal antibodies’ transmission through the placenta to the newborn and the persistence of the antibodies in babies’ serum. The objective of this study is to assess the maternal antibody transmission and kinetics among newborns in the first months of life. Women having received one or two doses of anti-SARS-CoV-2 mRNA-vaccines during pregnancy at any gestational age, and their newborns, were recruited and followed-up over 9 months. Ninety-eight women and 103 babies were included. At birth, we observed a significant positive correlation between maternal and neonatal serum anti-SARS-CoV-2 antibody levels and a significant negative correlation between the time since last dose and antibody levels in mothers with two doses. Over the follow-up, the birth antibody level significantly decreased in time according to the received doses number at 3, 6, and 9 months. During the follow-up, we registered 34 dyad SARS-CoV-2 infection cases. The decreasing trend was slower in the SARS-CoV-2 infection group and among breastfed non-infected babies. Antibodies from maternal anti-SARS-CoV-2 vaccination are efficiently transferred via the placenta and potentially even through breast milk. Among newborns, antibodies show relevant durability in the first months of life. Full article
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