State of the Art and Perspectives in Antimicrobial Peptides
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 1341
Special Issue Editor
Interests: antimicrobial peptide; self-assembling nanostructures based peptides; drug delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bacterial infections caused by ‘superbugs’ are increasing globally, and conventional antibiotics are becoming less effective against these bacteria. A strong modification of lifestyle is required since we risk reverting back to a pre-antibiotic era in terms of immunological protection. Within this context, antimicrobial peptides (AMPs), a class of small peptides that widely exist in nature and contribute to an organism’s defenses, have attracted researchers’ attention. Perspectives and applications are numerous and cover different fields. Although peptides present some weaknesses in membrane impermeability and poor stability in vivo, due to the intrinsic limitations of amino acids, extensive research has been carried out in terms of the discovery and optimization of peptide drugs in order to overcome these drawbacks. The use of chemical modification and integration of traditional lead peptide discovery methods with novel technologies, such as rational design models, provides a reliable approach for the development of effective and selective lead peptides in a short period of time. Moreover, the design of peptide-based nano-systems opens the door to new and important scenarios.
Prof. Dr. Annarita Falanga
Guest Editor
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Keywords
- antimicrobial peptides
- AMPs
- chemical modification of AMPs
- function
- structure
- synthesis
