Molecular Research on Hypertensive and Metabolic Disorders in Pregnancy

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Reproduction".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2865

Special Issue Editors


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Guest Editor
Department of OB/GYN, Baylor College of Medicine, Houston, TX, USA
Interests: vascular and metabolic adaptations in pregnancy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of OB/GYN, Baylor College of Medicine, Houston, TX 77030, USA
Interests: pregnancy and gestational diabetes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite many leaps forward, there is a continuous struggle with tragic, and often preventable, deaths related to poor maternal health. Poor maternal health and birth outcomes occur worldwide.  Improving the health of mothers and babies is an important public health priority. Cardiovascular disease constitutes nearly 30% of pregnancy-related deaths. Preeclampsia is a hypertensive pregnancy diagnosed before 20 weeks gestation that results in significant vascular and metabolic dysfunction in the mother and offspring, and neonatal morbidity and mortality. Preeclampsia is most common in women with gestational diabetes, a pregnancy complication caused by an inability to use sugar properly during pregnancy, and this may result in giving birth to a large baby. Gestational diabetes and preeclampsia are both conditions that only occur during pregnancy. Gestational diabetes with preeclampsia is a condition that may also be called toxemia of pregnancy or pregnancy-induced hypertension; this occurs in about 10 to 30 percent of women with gestational diabetes. The development of strategies for reducing the risk factors and complications, both acute and long-term, is crucial in decreasing the impact of the condition. Researchers and practitioners in the field are constantly searching for advancements in the prevention, care, and diagnosis of pregnancy disorders.

A Special Issue of Biomolecules has been organized to present a collection of innovative and high-quality research studies focused on “Molecular Research on Hypertensive  and Metabolic Disorders in Pregnancy”. We cordially invite authors to submit qualitative and quantitative studies and reviews addressing original research and case studies that fill gaps in the knowledge, or that provide an in-depth analysis of the present knowledge.

Dr. Madhulata Singh Chauhan
Dr. Yuanlin Dong
Guest Editors

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Keywords

  • pregnancy
  • high risk pregnancy
  • feto-placental growth
  • chronic and gestational hypertension
  • preeclampsia, gestational diabetes
  • spontaneous abortion
  • preterm birth

Published Papers (1 paper)

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Research

16 pages, 3045 KiB  
Article
Potential Causal Association between Plasma Metabolites, Immunophenotypes, and Female Reproductive Disorders: A Two-Sample Mendelian Randomization Analysis
by Hui-Hui Shen, Yang-Yang Zhang, Xuan-Yu Wang, Cheng-Jie Wang, Ying Wang, Jiang-Feng Ye and Ming-Qing Li
Biomolecules 2024, 14(1), 116; https://doi.org/10.3390/biom14010116 - 16 Jan 2024
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Abstract
Background: While extensive research highlighted the involvement of metabolism and immune cells in female reproductive diseases, causality remains unestablished. Methods: Instrumental variables for 486 circulating metabolites (N = 7824) and 731 immunophenotypes (N = 3757) were derived from a genome-wide association [...] Read more.
Background: While extensive research highlighted the involvement of metabolism and immune cells in female reproductive diseases, causality remains unestablished. Methods: Instrumental variables for 486 circulating metabolites (N = 7824) and 731 immunophenotypes (N = 3757) were derived from a genome-wide association study (GWAS) meta-analysis. FinnGen contributed data on 14 female reproductive disorders. A bidirectional two-sample Mendelian randomization study was performed to determine the relationships between exposures and outcomes. The robustness of results, potential heterogeneity, and horizontal pleiotropy were examined through sensitivity analysis. Results: High levels of mannose were found to be causally associated with increased risks of gestational diabetes (GDM) (OR [95% CI], 6.02 [2.85–12.73], p = 2.55 × 10−6). A genetically predicted elevation in the relative count of circulating CD28CD25++CD8+ T cells was causally related to increased female infertility risk (OR [95% CI], 1.26 [1.14–1.40], p = 1.07 × 10−5), whereas a high absolute count of NKT cells reduced the risk of ectopic pregnancy (OR [95% CI], 0.87 [0.82–0.93], p = 5.94 × 10−6). These results remained consistent in sensitivity analyses. Conclusions: Our study supports mannose as a promising GDM biomarker and intervention target by integrating metabolomics and genomics. Full article
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