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Biomolecules
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Bioactive Molecules in the Control of Oxidative Stress and Oxidative...
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Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 15 December 2024 | Viewed by 614

Special Issue Editor

Dr. Jian Yao

E-Mail Website
Guest Editor
Department of Advanced Biomedical Research, University of Yamanashi, Chuo Shi, Japan
Interests: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases

Special Issue Information

Dear Colleagues,

Oxidative stress is implicated in the pathogenesis of many diseases. This Special Issue will explore the potential of bioactive molecules obtained from natural, dietary, and endogenous sources to modulate oxidative stress and its associated pathologies. This Special Issue aims to compile cutting-edge research elucidating the antioxidant, anti-inflammatory, and cytoprotective mechanisms of these biomolecules. Contributions will cover recent findings related to the capabilities of these molecules to regulate free radical generation, influence redox signaling pathways and antioxidant defenses, and mitigate oxidative damage in cells, tissues and organs. Authors are invited to submit original research articles and authoritative reviews detailing the actions, molecular targets, and therapeutic potential of specific bioactive molecules against oxidative stress and oxidative stress-related diseases. By disseminating these discoveries, this Special Issue seeks to highlight bioactive molecules with promise regarding the prevention or deceleration of the progression of pathologies linked to oxidative stress.

Dr. Jian Yao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • bioactive molecules
  • ROS
  • redox signaling
  • oxidative stress-related diseases

Published Papers (1 paper)

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Research

12 pages, 1694 KiB  
Article
Apigenin Provides Structural Protection to Human Fibrinogen against Nitrosative Stress: Biochemical and Molecular Insights
by Aisha Farhana, Abdullah Alsrhani, Yusuf Saleem Khan, Mohammad Salahuddin, Mohammed Ubaidullah Sayeed and Zafar Rasheed
Biomolecules 2024, 14(5), 576; https://doi.org/10.3390/biom14050576 - 13 May 2024
Viewed by 305
Abstract
Background: Peroxynitrite (ONOO−) is an oxidant linked with several human pathologies. Apigenin, a natural flavonoid known for its health benefits, remains unexplored in relation to ONOO− effects. This study investigated the potential of apigenin to structurally protect fibrinogen, an essential [...] Read more.
Background: Peroxynitrite (ONOO−) is an oxidant linked with several human pathologies. Apigenin, a natural flavonoid known for its health benefits, remains unexplored in relation to ONOO− effects. This study investigated the potential of apigenin to structurally protect fibrinogen, an essential blood clotting factor, from ONOO−-induced damage. Methods: Multi-approach analyses were carried out where fibrinogen was exposed to ONOO− generation while testing the efficacy of apigenin. The role of apigenin against ONOO−-induced modifications in fibrinogen was investigated using UV spectroscopy, tryptophan or tyrosine fluorescence, protein hydrophobicity, carbonylation, and electrophoretic analyses. Results: The findings demonstrate that apigenin significantly inhibits ONOO−-induced oxidative damage in fibrinogen. ONOO− caused reduced UV absorption, which was reversed by apigenin treatment. Moreover, ONOO− diminished tryptophan and tyrosine fluorescence, which was effectively restored by apigenin treatment. Apigenin also reduced the hydrophobicity of ONOO−-damaged fibrinogen. Moreover, apigenin exhibited protective effects against ONOO−-induced protein carbonylation. SDS-PAGE analyses revealed that ONOO−treatment eliminated bands corresponding to fibrinogen polypeptide chains Aα and γ, while apigenin preserved these changes. Conclusions: This study highlights, for the first time, the role of apigenin in structural protection of human fibrinogen against peroxynitrite-induced nitrosative damage. Our data indicate that apigenin offers structural protection to all three polypeptide chains (Aα, Bβ, and γ) of human fibrinogen. Specifically, apigenin prevents the dislocation or breakdown of the amino acids tryptophan, tyrosine, lysine, arginine, proline, and threonine and also prevents the exposure of hydrophobic sites in fibrinogen induced by ONOO−. Full article
(This article belongs to the Special Issue Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases)
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