Biomaterials and Technology for Tumor Engineering

Dear Colleagues,

Spheroids, tumoroids, and cell-laden 3D scaffolding systems are commonly used as 3D tumor engineering models for the study of various tumorigeneses. Different biomaterials that could mimic the natural microenvironment with or without blended forms have significantly advanced tumor engineering. A complex in vitro heterogeneous tumor, which is representative of biologically relevant tumors, is not only necessary for tumor studies, for example, in proliferation, growth, and cell signatures, but is also equally important in discovering the efficacies of anticancer drugs. The implantation of 3D tumors into an animal is a common practice for generating xenograft tumors. However, we cannot precisely monitor the growth of the tumor, because of physiological, metabolic, and cell-signature complexities in animal tissue. In addition, we do not have a complete set of physiological systems that resemble the in vivo tissue environment yet; therefore, we rely on the outcomes of animal studies. Biomaterials which could provide a native-like microenvironment to the cells and which facilitate the monitoring of cell migration, proliferation, and kinetic development of the tumors are in demand in tumor-model engineering. In addition, this Special Issue will consider the application of imaging systems which could support the tracing of tumor development in animal tissues.

The topics of interest of this Special Issue therefore include, but are not limited to:

• Advancements in 3D tumor model engineering;
• Advancements in in vivo tumor imaging systems;
• Advancements in biomaterials;
• Advancements in tumor spheroids;
• Advancements in tumoroids;

Advancements in new protocols for blended biomaterials that could mimic native microenvironments.

Dr. Girdhari Rijal
Prof. Dr. Narayan Bhattarai
Guest Editors

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• three-dimensional tumor models
• xenograft tumors
• cancer cell signatures
• H-scan ultrasound
• in vivo imaging systems
• dye-tagged cell technologies
• scaffolds
• tumoroids
• spheroids
• anticancer drugs