Trends and Prospects in Binding Proteins

Dear Colleagues,

Three-dimensional protein folding dynamics represents the key control mechanism of protein to ligand, small molecules, macromolecules, DNA or RNA, as well as protein–protein interactions that underlie the protein functions obtained in living systems. Binding proteins, through their unique energetically favorable formations, are responsible for the nexus of the molecular pathways responsible for the biochemical reactions that take place in cells. Mutations, protein modifications, agonists or antagonists, and stoichiometric alterations result in a variety of different phenotypes, gain-of-function, leaky function, or deleterious effects associated with diseases, therapeutic approaches, and applications of biotechnological interest. Modern high-throughput proteomic, NMR, and X-ray crystallography protein structure analyses and bioinformatics shed light on the complex protein nature, while genetic engineering provides the means for target modifications and testing of protein function. This Special Issue of Applied Biosciences, “Trends and Prospects in Binding Proteins”, is dedicated to novel experimental research findings and to summaries of current trends and prospects in binding proteins biochemistry, cell biology, and applied biotechnology.

Dr. Demetrios A. Arvanitis
Guest Editor

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• binding proteins
• protein–ligand interactions
• protein–protein interactions
• protein structural analysis
• bioinformatics
• protein structure prediction
• protein interactome
• applied biochemistry