Next Article in Journal
Characterization of the Cytotoxic Effect of N-(2-Morpholinoethyl)-2-(naphthalen-2-yloxy)acetamide in Cells Derived from Cervical Cancer
Previous Article in Journal
A Molecular Docking Study on Natural Compounds as Anxiolytics and Antidepressants
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Medical Sciences Forum
Volume 14
Issue 1
10.3390/ECMC2022-13246
msf-logo
Submit to this Journal
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Abstract

Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization †

by
Cátia Venâncio
1,*,
Bruna Monteiro
2,
Rafael Francisco
3,
Márcia C. Neves
3,
Mara G. Freire
3,
Ana Catarina A. Sousa
4 and
Isabel Lopes
1
1
Centre for Environmental and Marine Studies (CESAM), University of Aveiro, 3810-193 Aveiro, Portugal
2
Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal
3
CICECO–Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
4
Department of Biology and Comprehensive Health Research Centre (CHRC), University of Évora, 7006-554 Évora, Portugal
*
Author to whom correspondence should be addressed.
†
Presented at the 8th International Electronic Conference on Medicinal Chemistry, 1–30 November 2022; Available online: https://ecmc2022.sciforum.net/.
Med. Sci. Forum 2022, 14(1), 101; https://doi.org/10.3390/ECMC2022-13246
Published: 1 November 2022
(This article belongs to the Proceedings of The 8th International Electronic Conference on Medicinal Chemistry)
Versions Notes

Abstract

:
Given the growing number of cancer diseases, new cytostatic drugs are approved daily, often with concomitant development, or refinement of some of these drugs aimed at decreasing patient discomfort during the administration period (e.g., prodrugs). Classified as highly toxic, they represent a major environmental problem that may potentiate disease occurrences. For newer cytostatic and prodrugs there are no (or few) reported effects to aquatic organisms; therefore, their prioritization is constrained. In light of the points raised, the IonCytDevice project intended to bridge some of these knowledge gaps and has delivered important benchmarks. Predictions have been obtained on the environmental impacts of three cytostatics (cyclophosphamide: CYP; 5-fluoroucil: 5-FU; and mycophenolic acid: MPA) and one prodrug (capecitabine: CAP) on freshwater biota, with a focus on new species and endpoints likely to be also framed in meta-analysis studies. The results reveal that, for now, CYP, 5-FU, and CAP (prodrug) pose no risk, whilst MPA was flagged as a high environmental risk.

Author Contributions

Conceptualization, C.V., A.C.A.S. and I.L.; methodology, M.C.N. and I.L.; validation, A.C.A.S. and I.L.; formal analysis, C.V. and B.M.; investigation, B.M., R.F.; resources, M.G.F. and I.L.; data curation, C.V., A.C.A.S. and I.L.; writing—original draft preparation, C.V. and B.M.; writing—review and editing, C.V., R.F., M.C.N.; M.G.F., A.C.A.S. and I.L.; visualization, C.V., A.C.A.S. and I.L.; supervision, M.G.F., A.C.A.S. and I.L.; project administration, M.G.F., A.C.A.S. and I.L.; funding acquisition, M.G.F. and I.L. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by FEDER, through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI), and by national funds (OE), through FCT/MCTES grant number POCI-01-0145-FEDER-031106 (IonCytDevice—PTCD/BTA-BTA/31106/2017).

Conflicts of Interest

The authors declare no conflict of interest.
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Venâncio, C.; Monteiro, B.; Francisco, R.; Neves, M.C.; Freire, M.G.; Sousa, A.C.A.; Lopes, I. Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization. Med. Sci. Forum 2022, 14, 101. https://doi.org/10.3390/ECMC2022-13246

AMA Style

Venâncio C, Monteiro B, Francisco R, Neves MC, Freire MG, Sousa ACA, Lopes I. Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization. Medical Sciences Forum. 2022; 14(1):101. https://doi.org/10.3390/ECMC2022-13246

Chicago/Turabian Style

Venâncio, Cátia, Bruna Monteiro, Rafael Francisco, Márcia C. Neves, Mara G. Freire, Ana Catarina A. Sousa, and Isabel Lopes. 2022. "Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization" Medical Sciences Forum 14, no. 1: 101. https://doi.org/10.3390/ECMC2022-13246

Article Metrics

Back to TopTop