Selenium-Based Drug Development for Antioxidant and Anticancer Activity
Round 1
Reviewer 1 Report
The article "Selenium-based Drug Development for Antioxidant and Anti-cancer Activity " is good work. However, please note the following points for revision consideration:
1. Please explain the classification of compounds containing selenium in the section of anticancer activity. I suggest you provide a more detailed explanation of how to divide rather than just a general description. In addition, what are the basic principles on which the division method is based? Mechanism or structure?
2. It is suggested that a table can be used to categorize selenium-containing compounds, along with their structural and mechanism characteristics, for easier identification.
3. The conclusion section should be based on anticancer and antioxidant drugs containing selenium, whereas there has not been a single instance of such drugs. As a result, this part requires thorough correction and revision to be accurate and comprehensive.
Author Response
Dear reviewer,
Thank you very much for your comments on our review paper. We have revised the manuscript according to the comments carefully and would like to submit it for your consideration. We have made modifications to the manuscript using the track changes mode.
Point-by-point responses to the reviewers’ comments are listed in the following.
- Please explain the classification of compounds containing selenium in the section of anticancer activity. I suggest you provide a more detailed explanation of how to divide rather than just a general description. In addition, what are the basic principles on which the division method is based? Mechanism or structure?
Reply: Thanks for your reasonable advice. We have added the classification of compounds containing selenium in the section of anticancer activity. We also added the explanation of structure based division of the compounds in the section of anticancer activity. New table (Table 1) have been incorporated to show the unique chemical functionality for each category.
- It is suggested that a table can be used to categorize selenium-containing compounds, along with their structural and mechanism characteristics, for easier identification.
Reply: New table (Table 1) have been incorporated to show the unique chemical functionality for each category.
- The conclusion section should be based on anticancer and antioxidant drugs containing selenium, whereas there has not been a single instance of such drugs. As a result, this part requires thorough correction and revision to be accurate and comprehensive.
Reply: Thanks for your recommendation. We have modified the conclusion section to focus on anticancer and antioxidant drugs.
Sincerely,
Dr. Sashi debnath
Reviewer 2 Report
The work, I received for review, summarizes the current status of the literature regarding the potential role of selenium-based compounds for antioxidant and anticancer treatment. Thus, it is an important subject in drug research that may be interesting for Future Pharmacology readers. The manuscript cites many current references. The layout of the work is well thought out, and all data are presented in an orderly and logical manner. Overall, the manuscript is complete and nicely written. However, it needs some changes. I recommend this article for further consideration after incorporating the minor changes given below.
- Explain the abbreviation ‘UPR’ (line 188) and ‘PARP’ (line 189) at the first use.
- Include the references to figures in the text.
- I suggest extending the manuscript with a short chapter on selenium-based nanomedicine.
- In the text there are some typographic or grammatical errors (e.g., double or lack of spaces) that should be corrected before publication.
With kind regards,
Reviewer
Author Response
Dear reviewer,
Thank you very much for your comments on our review paper. We have revised the manuscript according to the comments carefully and would like to submit it for your consideration. We have made modifications to the manuscript using the track changes mode.
Point-by-point responses to the reviewers’ comments are listed in the following.
- Explain the abbreviation ‘UPR’ (line 188) and ‘PARP’ (line 189) at the first use.
Reply: Thanks for your advice. This abbreviations are corrected in the revised manuscript.
- Include the references to figures in the text.
Reply: Thanks for your recommendation. References have been added to the figure text.
- I suggest extending the manuscript with a short chapter on selenium-based nanomedicine.
Reply: Thanks for your suggestion. Selenium-based nanomedicines are very exciting and a huge attention have been given to Selenium-based nanomedicines for medical practice and drug delivery. We will describe the latest outcome for selenium-based nanomedicines in our future publication.
- In the text there are some typographic or grammatical errors (e.g., double or lack of spaces) that should be corrected before publication.
Reply: Thanks for the reasonable suggestion. We made a throughout check for the typographic or grammatical errors.
Sincerely
Dr. Sashi debnath
