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Systematic Review
Peer-Review Record

Acute Vessel Closure or Major Adverse Cardiac Events of Drug-Coated Balloons and Stents: A Systematic Review and Meta-Analysis

BioMed 2022, 2(4), 442-451; https://doi.org/10.3390/biomed2040035
by Tharusha Gunawardena 1,2,†, Natasha Corballis 1,2,†, Ioannis Merinopoulos 1,2, Vasiliki Tsampasian 1,2,*, Johannes Reinhold 1,2, Simon Eccleshall 1 and Vassilios S. Vassiliou 1,2
Reviewer 1:
Reviewer 2: Anonymous
BioMed 2022, 2(4), 442-451; https://doi.org/10.3390/biomed2040035
Submission received: 2 November 2022 / Revised: 24 November 2022 / Accepted: 12 December 2022 / Published: 15 December 2022

Round 1

Reviewer 1 Report

The interesting work is about the comparison of acute vascular closure between DCB and DES. However, the search term did not include acute vascular closure. The majority of enrolled studies did not have events of acute vascular closure. Therefore, the work seems to discuss the results after PCI with DCB and DES in different clinical conditions (including MI, high-bleeding risk, and all conditions).

Major comments:

1. Could the author provide the subgroup analysis between different clinical conditions?

2. The reference number seems to be an error. The author needs to modify.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

In this paper Gunawardena et al give a Systematic review and meta-analysis of  Acute vessel closure or major adverse cardiac events of DEB vs Stent 

The topic is interesting and innovative and the paper is very clear and well-written. The limitations are well rapresented.

My comments

The part of meta-analysis is very good but as the review is weak, I suggest removing or modulating the "A Systematic Review".

In the discussion the authors should stress the topic that  an acute vessel closure of a native coronary is very rare after DEB, instead, the acute closure after stenting could be more common for many reasons (stent under expansion, thrombosis related to polymer...)

 

 

Author Response

Please see the attachment

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The author responded to the comments and showed no significant difference between selective and STEMI patients. Even though there is no positive finding, this meta-analysis suggests that using DCBs is a safe alternative to stents when treating coronary artery disease and had the trend of improving acute closure.

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