Automated Methods for Tuberculosis Detection/Diagnosis: A Literature Review
Abstract
:1. Introduction
2. Importance of Microscopy
Disadvantages of Microscopy and Motivation for Computer-Based Automatic Detection
- What datasets of TB microscopy images are available online, and what microscopy methods were used to generate them?
- What challenges to the development of AI image analysis methods are presented by the level of variability in currently available TB microscopy image datasets?
- What metrics have been employed previously to assess the efficacy of AI techniques in the analysis of TB microscopy images, and what are their respective advantages and limitations?
- What specific machine learning (ML) and deep learning (DL) techniques have been performed for TB microscopy image analysis, and what knowledge can be distilled from their applications in approaches that did and did not work?
3. Datasets
Paper | Year | Microscopy Type | Region of Image Generation | Region of Method Development | Purpose of Research | AI Method Used | Dataset Online |
---|---|---|---|---|---|---|---|
Veropoulos et al. [26] | 1998 | Fluorescence | N/A | Europe | Diagnosis | ML | No |
Forero-Vargas et al. [27] | 2002 | Brightfield | N/A | Europe | Detection | ML | No |
Forero et al. [28] | 2003 | Fluorescence | Europe | Europe | Detection | ML | No |
Forero et al. [29] | 2004 | Fluorescence | Europe | Europe | Detection | ML | No |
Forero et al. [30] | 2006 | Fluorescence | Europe | Europe | Detection | ML | No |
Sadaphal et al. [31] | 2008 | Brightfield | America | America | Detection | ML | Yes [21] |
Costa et al. [32] | 2008 | Brightfield | America | America | Detection | ML | No |
Makkapati et al. [20] | 2009 | Brightfield | N/A | Asia | Detection | ML | No |
Sotaquŕa et al. [33] | 2009 | Brightfield | America | America | Quantification | DL | No |
Khutalang et al. [34] | 2010 | Brightfield | Africa | Africa | Detection | ML | No |
Osman et al. [35] | 2010 | Brightfield | Asia | Asia | Diagnosis | ML | No |
Osman et al. [36] | 2010 | Brightfield | Asia | Asia | Diagnosis | ML | No |
Osman et al. [37] | 2010 | Brightfield | Asia | Asia | Diagnosis | ML | No |
Zhai et al. [38] | 2010 | Brightfield | N/A | Asia | Detection | ML | No |
Nayak et al. [39] | 2010 | Brightfield | Asia | Asia | Quantification | DL | No |
Chang et al. [40] | 2012 | Flueorescence | Africa | America | Diagnosis | ML | No |
Costa-Filho et al. [41] | 2012 | Brightfield | America | America | Detection | ML | Yes [23] |
Santiago-mozos et al. [42] | 2014 | Brightfield | N/A | Europe | Diagnosis | ML | No |
Ayas & Ekinci [43] | 2014 | Brightfield | Asia | Asia | Detection | ML | No |
Costa-Filho et al. [44] | 2015 | Brightfield | America | America | Detection | ML | Yes [23] |
Govindan et al. [45] | 2015 | Brightfield | America | Asia | Detection | ML | Yes (partially) [21] |
Gosh & Nasipuri [46] | 2016 | Brightfield | Asia | Asia | Diagnosis | ML | No |
Priya et al. [47] | 2016 | Brightfield | Africa | Asia | Detection | ML | No |
Soans et al. [48] | 2016 | Brightfield | N/A | Africa | Quantification | DL | No |
López et al. [49] | 2017 | Brightfield | N/A | America | Detection | DL | No |
Yan & Zhuang [50] | 2018 | Brightfield | Asia | Asia | Detection | ML | Yes [23] |
Kant & Srivastava [3] | 2018 | Brightfield | N/A | Asia | Diagnosis | DL | No |
Panicker et al. [51] | 2018 | Brightfield | America | Asia | Detection | DL | Yes |
Samuel & Kanna [52] | 2018 | Brightfield | Asia | Asia | Detection | DL | Yes |
Xiong et al. [53] | 2018 | Brightfield | Asia | Asia | Diagnosis | DL | No |
Mithra & Emmanuel [54] | 2018 | Brightfield | Asia | Asia | Quantification | DL | Yes [24] |
Díaz-Huerta et al. [55] | 2019 | Brightfield | America | America | Detection | ML | No |
Ahmed et al. [56] | 2019 | Brightfield | N/A | Asia | Diagnosis | DL | No |
Hu et al. [57] | 2019 | Brightfield | Asia | Asia | Diagnosis | DL | No |
El-Melegy et al. [19] | 2019 | Brightfield | Asia | Africa | Detection | DL | No |
Mithra & Emmanuel [54] | 2019 | Brightfield | Asia | Asia | Diagnosis | DL | Yes [24] |
Vente et al. [58] | 2019 | Fluorescence | Africa | Europe | Quantification | DL | No |
Yousefi et al. [59] | 2020 | Brightfield | N/A | America | Detection | ML | No |
Serrão et al. [60] | 2020 | Brightfield | America | America | Detection | DL | No |
Swetha et al. [61] | 2020 | Brightfield | N/A | Asia | Diagnosis | DL | No |
Zachariou et al. [62] | 2022 | Fluorescence | Africa | Europe | Detection | DL | No |
Zachariou et al. [63] | 2022 | Fluorescence | Africa | Europe | Quantification | DL | No |
Challenges with Dataset Standardisation
4. Evaluation of Performance Metrics
4.1. Classification Metrics
- AUC = 0.5:
- The model fails to exhibit superior performance when compared to random guesses.
- AUC > 0.5:
- The model outperforms random guessing, with greater AUC values indicating superior performance.
- AUC = 1.0:
- The model has perfect discriminatory power, achieving a true-positive rate of 1 and a false-positive rate of 0.
4.2. Regression Metrics
4.3. Segmentation Metrics
5. Research Utilising ML
5.1. Image Gradient-Based Approaches
5.2. Stochastic-Based Approaches
6. Research Utilising DL
6.1. Custom-Made CNN Architectures
6.2. Automatic Creation of FOVs
6.3. Gradient-Based Approaches
6.4. Employing Existing Models for Mtb Feature Extraction
7. Research on Mtb Bacteria Quantification
8. Discussion
9. Conclusions
- A collection of publicly available datasets has been curated, encompassing relevant extracted data along with any supplementary annotations.
- We conclude that the provision of guidelines for both datasets and evaluation metrics is crucial in establishing standardisation. This will enable researchers to universally compare and assess their approaches.
- We have conducted a comprehensive review of existing DL/ML methods on TB–AI, specifically focusing on their application in medical diagnosis, cell detection, and cell quantification. Furthermore, we have critically examined the merits and limitations of these methods.
Author Contributions
Funding
Conflicts of Interest
References
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Image Dataset Name | URL | Content of Dataset | Image Annotation | Label Type |
---|---|---|---|---|
CDC Public Health Image Library [21] | phil.cdc.gov (accessed on 22 August 2023) | Microscopy images within general collection of TB-related images, 25 brightfield slides 15 fluorescence slides | None | N/A |
Kaggle Tuberculosis Image Dataset [22] | kaggle.com/datasets/saife245/tuberculosis-image-datasets (accessed on 22 August 2023) | 1265 brightfield images | Yes | Bounding Boxes |
TB_IMAGES_DB_BACILLI.V1 [23] | Free access can be applied for at tbimages.ufam.edu.br (accessed on 22 August 2023) | 120 brighfield images | Yes | Bounding Boxes |
ZNSM-iDB [24] | drive.google.com/drive/folders/1HPcJzwKi76WwCFYj7dHUgVA31dAyFyTF (accessed on 22 August 2023) | 9 sets of brightfield images (50–90 images per set) | Yes | Bounding Boxes |
TBDB [25] | Freely available by contacting the authors | 3102 brightfield images | Yes | Not specified |
Paper | Hausdorff Distance | Jaccard Index | SD |
---|---|---|---|
Khutlang et al. [66] | 0.96 | N/A | N/A |
Soans et al. [48] | 0.06 | N/A | 87% |
Diaz-Huerta et al. [55] | N/A | 96% | N/A |
Mithra & Sam Emmanuel [54] | N/A | 95% | N/A |
Zachariou et al. [63] | N/A | 94% | 89% |
Paper | Accuracy | Sensitivity/Recall | Specificity |
---|---|---|---|
Veropoulos et al. [26] | 97.90% | 94.10% | 99.10% |
Forero-Vargas et al. [27] | N/A | N/A | 91.00% |
Forero et al. [28] | N/A | 93.30% | 91.68% |
Forero et al. [29] | N/A | 86.66% | 99.74% |
Forero et al. [30] | N/A | 94.67% | 98.10% |
Sadaphal et al. [31] | N/A | N/A | N/A |
Costa et al. [32] | N/A | 76.65% | 88.65% |
Makkapati et al. [20] | N/A | N/A | N/A |
Khutalang et al. [66] | 86.85% | 99.95% | 77.62% |
Osman et al. [36] | 86.32% | N/A | N/A |
Osman et al. [35] | 98.07% | 100.00% | 96.19% |
Osman et al. [37] | N/A | N/A | N/A |
Zhai et al. [38] | N/A | 100.00% | 94.00% |
Chang et al. [40] | N/A | 92.30% | 88.00% |
Santiago-Mozos et al. [42] | N/A | 73.53% | 99.99% |
Ayas et al. [43] | N/A | 75.77% | 96.97% |
Costa-Filho et al. [16] | 91.45% | 93.41% | 89.50% |
Costa-Filho et al. [44] | 93.25% | 93.75% | 88.46% |
Govindan et al. [45] | N/A | 72.89% | N/A |
Gosh et al. [46] | N/A | 93.90% | 88.20% |
Priya et al. [47] | 91.30% | 91.59% | 88.46% |
Aymas et al. [67] | 70.52% | N/A | N/A |
Yan et al. [50] | N/A | 97.46% | 93.99% |
Diaz-Huerta et al. [55] | 98.66% | N/A | N/A |
Paper | Accuracy | Sensitivity/Recall | Specificity |
---|---|---|---|
Lopez et al. [49] | N/A | N/A | N/A |
Kant et al. [3] | 99.80% | 83.78% | N/A |
Panicker et al. [51] | N/A | 97.13% | N/A |
Samuel et al. [52] | 95.05% | N/A | N/A |
Xiong et al. [53] | N/A | 97.94% | 83.65% |
Ahmed et al. [56] | 96.07% | N/A | N/A |
Hu et al. [57] | 98.40% | 98.00% | 98.4% |
El-Melegy et al. [19] | N/A | 98.4% | N/A |
Mithra et al. [70] | 97.55% | 97.86% | 98.23% |
Serao et al. [60] | 99.67% | 99.98% | 99.34% |
Zachariou et al. [62] | N/A | 89.02% | 100% |
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Zachariou, M.; Arandjelović, O.; Sloan, D.J. Automated Methods for Tuberculosis Detection/Diagnosis: A Literature Review. BioMedInformatics 2023, 3, 724-751. https://doi.org/10.3390/biomedinformatics3030047
Zachariou M, Arandjelović O, Sloan DJ. Automated Methods for Tuberculosis Detection/Diagnosis: A Literature Review. BioMedInformatics. 2023; 3(3):724-751. https://doi.org/10.3390/biomedinformatics3030047
Chicago/Turabian StyleZachariou, Marios, Ognjen Arandjelović, and Derek James Sloan. 2023. "Automated Methods for Tuberculosis Detection/Diagnosis: A Literature Review" BioMedInformatics 3, no. 3: 724-751. https://doi.org/10.3390/biomedinformatics3030047