Improving Traditional Post Mortem Healthcare—The Cross-Sectional Use of Blood-Based Biomarkers
Abstract
:1. Introduction
2. Traditional Post Mortem Healthcare
3. Options for Traditional Autopsy
4. Post Mortem Biomarkers
5. Biomarkers of Vascular Quiescence
5.1. Circulating Markers of the Extracellular Matrix: Biomarkers Related to the Vascular Wall
5.2. Proteins Associated with Vascular Lumen: Inflammation and Thrombosis Biomarkers
6. Vascular Cognitive Impairment: Room for Biomarkers at Post Mortem
7. Applying Clinical Biomarkers in a Post Mortem Setting
8. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Related Process | Biomarker | Medium | Reference Values | Half-Life |
---|---|---|---|---|
Inflammation | CRP | S | <0.3 mg/dL: normal 0.3 to 1.0 mg/dL: normal to minor elevation (can be seen in obesity, pregnancy, diabetes, common cold, gingivitis, periodontitis, sedentary lifestyle, cigarette smoking, and genetic polymorphisms) [130]. | ~19 h [99] |
OPT | S | 122.3 ± 39.2 ng/mL | 5 to 15 h [122] | |
P | 463.7 ng/mL–587.0 ng/mL [131]. | |||
Related to thrombus | D-dimer | S | <2152 ng/mL [132]. | 4 to 6 h [111] |
Matrix-degrading enzymes | MMP-9 | S | 436 ng/mL (range, 169–705 ng/mL) [133]. | Short [83] |
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Šoša, I. Improving Traditional Post Mortem Healthcare—The Cross-Sectional Use of Blood-Based Biomarkers. Forensic Sci. 2023, 3, 368-380. https://doi.org/10.3390/forensicsci3030028
Šoša I. Improving Traditional Post Mortem Healthcare—The Cross-Sectional Use of Blood-Based Biomarkers. Forensic Sciences. 2023; 3(3):368-380. https://doi.org/10.3390/forensicsci3030028
Chicago/Turabian StyleŠoša, Ivan. 2023. "Improving Traditional Post Mortem Healthcare—The Cross-Sectional Use of Blood-Based Biomarkers" Forensic Sciences 3, no. 3: 368-380. https://doi.org/10.3390/forensicsci3030028