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Volume 6
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10.3390/I3S2021Dresden-10174
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Abstract

Hemocompatible Electrochemical Sensors for Continuous Monitoring of Blood Parameters †

by
Sascha Balakin
1,2,*,
Bergoi Ibarlucea
1,2,3,
Dmitry Belyaev
1,2,
Larysa Baraban
2,4,
Stefanie Hänsel
2,5,
Manfred Maitz
2,5,
Carsten Werner
2,5 and
Gianaurelio Cuniberti
1,2,3
1
Institute for Materials Science and Max Bergmann Center for Biomaterials, Technische Universität Dresden, 01069 Dresden, Germany
2
Else Kröner-Fresenius Center for Digital Health (EKFZ), Technische Universität Dresden, 01307 Dresden, Germany
3
Center for advancing electronics Dresden (CFAED), Technische Universität Dresden, 01069 Dresden, Germany
4
Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, 01328 Dresden, Germany
5
Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, 01069 Dresden, Germany
*
Author to whom correspondence should be addressed.
†
Presented at the 8th International Symposium on Sensor Science, 17–28 May 2021; Available online: https://i3s2021dresden.sciforum.net/.
Eng. Proc. 2021, 6(1), 19; https://doi.org/10.3390/I3S2021Dresden-10174
Published: 21 May 2021
(This article belongs to the Proceedings of The 8th International Symposium on Sensor Science)
Versions Notes

Abstract

:
The real-time monitoring of physiological parameters is essential for point-of-care testing. While nowadays routine tests are done through ex vivo analysis on frequently extracted blood, placing implantable sensors monitoring key blood parameters such as lactate, glucose, ions, and oxygen would mean a giant step forward in the care of critically ill patients, improving the response time in emergencies and diminishing the invasiveness of the measurements. The recent advances in microelectronics and nanotechnology are a promising technology enabling moving in that direction. The goal of our work is to develop arrays of electrochemical sensors with selective and hemocompatible coatings, allowing for the future implementation of such measurements in patients. We perform the analysis of blood parameters in a label-free and electrochemical manner which is compatible with the inevitable miniaturization in a real application. The tuneable composition of the layer will allow to pursue further applications in the future by modification of the receptor molecules and their concentrations.

Author Contributions

Conceptualization, B.I., D.B., L.B., S.B., M.M., S.H., C.W. and G.C.; methodology, M.M., B.I. and S.B.; validation, M.M., S.B. and B.I.; formal analysis, S.B. and B.I.; investigation, M.M., S.B. and S.H.; writing—original draft preparation, B.I. and S.B.; writing—review and editing, B.I. and S.B.; supervision, C.W. and G.C.; project administration, B.I., M.M. and L.B.; funding acquisition, B.I., C.W., M.M. and G.C. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by the Else Kröner-Fresenius Center for Digital Health and TU Dresden.

Conflicts of Interest

The authors declare no conflict of interest.
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Share and Cite

MDPI and ACS Style

Balakin, S.; Ibarlucea, B.; Belyaev, D.; Baraban, L.; Hänsel, S.; Maitz, M.; Werner, C.; Cuniberti, G. Hemocompatible Electrochemical Sensors for Continuous Monitoring of Blood Parameters. Eng. Proc. 2021, 6, 19. https://doi.org/10.3390/I3S2021Dresden-10174

AMA Style

Balakin S, Ibarlucea B, Belyaev D, Baraban L, Hänsel S, Maitz M, Werner C, Cuniberti G. Hemocompatible Electrochemical Sensors for Continuous Monitoring of Blood Parameters. Engineering Proceedings. 2021; 6(1):19. https://doi.org/10.3390/I3S2021Dresden-10174

Chicago/Turabian Style

Balakin, Sascha, Bergoi Ibarlucea, Dmitry Belyaev, Larysa Baraban, Stefanie Hänsel, Manfred Maitz, Carsten Werner, and Gianaurelio Cuniberti. 2021. "Hemocompatible Electrochemical Sensors for Continuous Monitoring of Blood Parameters" Engineering Proceedings 6, no. 1: 19. https://doi.org/10.3390/I3S2021Dresden-10174

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