Quinoa’s Potential to Enhance Dietary Management of Obesity and Type-2 Diabetes: A Review of the Current Evidence

Round 1

Reviewer 1 Report

The Authors proposed a paper entitled “Quinoa’s potential to enhance dietary management of obesity

and type-2 diabetes: a review of the current evidence” for the publication in Diabetology, MDPI.

The paper is worth of investigation and deserves to be published after some revisions listed in the following.

The problem of Table 1 is mainly the high amount of information. I suggest compacting it, maybe eliminating or reducing the “findings” column, and providing this further information directly in the manuscript, as a comment to the table.

Recalling the literature, could you provide data or information about the HbA1c comparison before and after the introduction of Quinoa in the type2 patient diet?

Is it possible to measure the HbA1c also to mice? if yes, what is the threshold value for diabetes?

Line 31. define CDC that appears for the first time.

Line 38. I know that this is a well-known concept about insulin resistance, but a reference could be added here.

Line 40. Based on the US inhabitants, could you add a numerical data of how many type2 diabetic are there in the united states (with proper reference time)? this could help having an idea of the problem.

I would also talk about glycemic index in this introduction, if possible.

Line 56. I suggest writing this sentence in another manner “it can be grown at sea level and at altitudes of up to 4000 meters”

Uniform “end user” of Line 62 with “end-users” of line 64.

Line 71. please, provide a brief description of “functional food”.

I suggest adding an abbreviation list to collect all the acronyms reported in this work.

Line 396. are you sure that “aggressively” is the best choice?

Thank you

Author Response

Please see attachment. 

Author Response File: Author Response.docx

Reviewer 2 Report

This paper is a good summary of Quinoa's role in type 2 diabetes. The authors well described the results of the recent reports about human/animal studies and possible mechanisms in this paper. 

However, there are some points to be improved.

1. Quinoa's glycemic index is 53. The beneficial effects of Quinoa might be due to its nutrient composition (low Carbohydrate and high fiber). So authors should this effect in discussion after comparing the effects of Quinioa's benefit with other low Carb, high fiber foods.

      2. There are several typo mistakes. For example, 

        Table 1 Mouse - 6 wk male -> 6 wk, male 

 

  

  

Author Response

Please see attachment. 

Author Response File: Author Response.docx