Obstructive Sleep Apnea and Risk of Miscarriage

Round 1

Reviewer 1 Report

It is quite an interesting manuscript. The topic of this manuscript falls within the scope of  Reproductive Medicine.

The Authors have presented sufficient data. The appropriate tables and figures have been provided. The article is easy to read and logically structured.  The methods are adequately described. The authors used appropriate statistical methods. The conclusions are consistent with the presented evidence and arguments.

the strength of this paper: very interesting topic; material and methods-the right choice of methodology methods, which were presented incomprehensible way; the obtained results are presented in the form of figures and tables, which are clear and easy to understand; the discussion- supports the results properly and refers to the current literature inappropriate manner; the conclusions- based on the obtained results, they are consistent with evidence and arguments. They address the main question posed.  The Authors used appropriate references.

 

There are only some  comments in the reviewer's opinion that should be taken under consideration by the Author:

·       In the introduction, line 52, please add that  OSA also increases oxidative stress [ please cite: PMID: 34336121]  

Obstructive sleep apnea can result in upregulation of  sympathetic nervous system activity, renin-angiotensin, aldosterone system activity,  endothelial dysfunction, inflammation, oxidative stress, and metabolic dysregulation, which can result in serious morbidity, including hypertension and cardiovascular diseases in the general population.[11, PMID: 34336121]

• Descriptions of tables should be above the tables.

Author Response

Dear Reviewer,

Thank you for your review. My responses are below.

The Authors have presented sufficient data. The appropriate tables and figures have been provided. The article is easy to read and logically structured.  The methods are adequately described. The authors used appropriate statistical methods. The conclusions are consistent with the presented evidence and arguments.	Thank you. No changes made.
the strength of this paper: very interesting topic; material and methods-the right choice of methodology methods, which were presented incomprehensible way; the obtained results are presented in the form of figures and tables, which are clear and easy to understand; the discussion- supports the results properly and refers to the current literature inappropriate manner; the conclusions- based on the obtained results, they are consistent with evidence and arguments. They address the main question posed.  The Authors used appropriate references.	Thank you. No changes made.
There are only some  comments in the reviewer's opinion that should be taken under consideration by the Author: ·       In the introduction, line 52, please add that  OSA also increases oxidative stress [ please cite: PMID: 34336121]  Obstructive sleep apnea can result in upregulation of  sympathetic nervous system activity, renin-angiotensin, aldosterone system activity,  endothelial dysfunction, inflammation, oxidative stress, and metabolic dysregulation, which can result in serious morbidity, including hypertension and cardiovascular diseases in the general population.[11, PMID: 34336121]	Thank you. This has been added. Line 54 and reference 12
Descriptions of tables should be above the tables.	Thank you. This has been corrected. Table 1, 2A, 2B, and 3

 

Author Response File: Author Response.docx

Reviewer 2 Report

Dear Authors

A) There are grammatical errors that you should re-edit the text.

B) Please add the full name of the abbreviation below each table or figure.

C) Please add the meaning of bold numbers in tables.

D) Please write P-value in italic.

E) Please re-edit Table 2.

 

 

Author Response

Dear Reviewer 2,

Thank you for your review. Our responses are below.

A) There are grammatical errors that you should re-edit the text.	Thank you. The text has been reviewed and identified errors have been corrected.
B) Please add the full name of the abbreviation below each table or figure.	Thank you. These have been added to tables 1, 2A, 2B, and 3
C) Please add the meaning of bold numbers in tables.	Thank you. This has been added to tables 1, 2A, 2B, and 3
D) Please write P-value in italic.	Thank you. These have been changed to italic font. Tables 1, 2A, 2B, and 3 and results section.
E) Please re-edit Table 2.	Thank you. We have adjusted the sizes of columns so that each portion of table 2A and 2B fit on one page.

 

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

Dear

The manuscript is acceptable in recent form.