Recent Advances of Magnetic Gold Hybrids and Nanocomposites, and Their Potential Biological Applications
, Kalsoom Saleem 1, Mirza Muhammad Faran Ashraf Baig 3, Muhammad Naeem Aamir 4, Minglian Wang 5,*, Xiuli Gao 6, Muhammad Abbas 1,* and Masood Ur Rehman 1,*Round 1
Reviewer 1 Report
The author presented the paper "Recent advances of Magnetic Gold Hybrids and Nanocomposites, and their Potential Biological Applications"
1) I recommend inserting some 2022 year new citations such as "Fe3O4@Au core–shell hybrid nanocomposite for MRI-guided magnetic targeted photo-chemotherapy" and some others, but it is on your consideration.
2) In the synthesis section I haven't seen any relevant discussion of the sizes of the nanoparticles in the context of the possible use for biomedical applications. Also, I haven't seen the sizes and stability investigations in each section. Maybe some Tables with some information about size, colloidal stability, biological liquids stability, physical (magnetic, MRI, thermomagnetism, etc.) are required. It will significantly improve the Review.
3) According to the topics of Magnetochemistry J. I highly recommend presenting more physical properties, clear examples, and comparisons. The section Biomedical Applications of mGNP may be improved.
For example subsection mGNP as Imaging Agents looks limited. We see that due to the Fe3O4 core it is possible to use it in MRI. However, the information on the influence of the Au coating on the MRI signal is not presented. Is it good to coat magnetic nanoparticles or it is very bad for MRI and water interaction.
4) Moreover, due to the presented material it is difficult to understand is this approach (gold coating) is much better than protein or artificial polymers coating for physical properties, toxicity, biodegradation, and elimination from the body. Maybe one more small section as a comparison with existing approaches is required.
Author Response
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Author Response File: 
Author Response.pdf
Reviewer 2 Report
line 21: different -> various
line 23: please explain Brust Schiffrin briefly
line 47: ,. -> remove the comma
line 93 and 379: consider the pagebreak (rather to the editor)
Fig. 1 and Fig. 2 are dislocated and too large; Fig. 2 looks contorted. - own source? else: cite! I like the figures, please at more of those schematics in the other subsections. It helps to understand the mechanisms at a glance.
line 506: Chen et al.
Chapter 3: I would encourage the authors to summarize the use of the respective mGNP and the application fields in a table as an overview.
line 531/532: Au-/Fe is strange
Conlusion & Outlook: I would expect a more more detailed and extended section; e.g. what are the most promising applications for mGNP, which application areas were not sucessful, where are other possible application fields to be investigated, additional needs etc. and waht is expected as the overall future for mGNPs - same as during the last six years?
Literature: I was astonished that no paper from Nadja Bigall from the University of Hannover was cited.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
Thank you for the revised paper.
